{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:04:13Z","timestamp":1777727053234,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between the uric acid-to-albumin ratio and adverse clinical outcomes in patients with hypertrophic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, observational single-center study included 124 patients with hypertrophic cardiomyopathy (58 with obstructive and 66 with nonobstructive hypertrophic cardiomyopathy) and 60 age- and sex-matched healthy controls. Baseline clinical, laboratory, and echocardiographic parameters were analyzed. A composite endpoint comprising cardiovascular death, heart failure hospitalization, and appropriate implantable cardioverter-defibrillator shocks was assessed. Logistic regression analyses were used to identify independent associations, and receiver operating characteristic analysis was performed to evaluate discriminative ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The uric acid-to-albumin ratio was higher in patients with obstructive hypertrophic cardiomyopathy than in those with nonobstructive hypertrophic cardiomyopathy and controls (1.56\u2009\u00b1\u20090.15 vs 1.21\u2009\u00b1\u20090.08 vs 1.15\u2009\u00b1\u20090.11;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adverse events occurred in 32 patients with hypertrophic cardiomyopathy (25.8%) and were more frequent in the obstructive group (34.5% vs 18.2%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.038). In multivariable analysis, higher uric acid-to-albumin ratio (per 0.1 increase; OR, 1.50; 95% confidence interval: 1.18\u20131.90;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001) and septal thickness (OR, 1.65; 95% confidence interval: 1.30\u20132.10;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independently associated with adverse outcomes. Receiver operating characteristic analysis yielded an area under the curve of 0.717 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated uric acid-to-albumin ratio was independently associated with adverse outcomes in hypertrophic cardiomyopathy and may serve as a simple and inexpensive biomarker for risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251412623","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:16:33Z","timestamp":1769055393000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between uric acid-to-albumin ratio and clinical outcomes in patients with hypertrophic cardiomyopathy: A retrospective observational study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-3651","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"\u00dclgen Kunak","sequence":"first","affiliation":[{"name":"Ministry of Health Antalya Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Kunak","sequence":"additional","affiliation":[{"name":"Akdeniz University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.023"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.045"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31321-6"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.14744\/AnatolJCardiol.2023.2805"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.05.046"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.04.014"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/00033197221110700"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050373"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d8190"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_8_15_2","first-page":"281","article-title":"Uric acid is associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy","volume":"18","author":"Gao J","year":"2021","unstructured":"Gao J, Shao CL, Meng XB, et\u00a0al. Uric acid is associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy. J Geriatr Cardiol 2021; 18: 281\u2013288.","journal-title":"J Geriatr Cardiol"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009734.2020.1719245"},{"key":"e_1_3_8_17_2","first-page":"111","article-title":"Evaluation of the association between serum uric acid level and the predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy","volume":"46","author":"\u00d6zy\u0131lmaz S","year":"2018","unstructured":"\u00d6zy\u0131lmaz S, Sat\u0131lm\u0131\u015fo\u011flu MH, G\u00fcl M, et\u00a0al. Evaluation of the association between serum uric acid level and the predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy. 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