{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:48:34Z","timestamp":1791953314221,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether rapid intracoronary adenosine administration attenuates percutaneous coronary intervention (PCI)\u2013induced systemic inflammation and oxidative stress in patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, randomized controlled trial enrolled patients undergoing coronary angiography (coronary angiography group) or PCI. Patients undergoing PCI were assigned to receive intracoronary adenosine (PCI + adenosine group) or placebo (PCI group). Blood levels of inflammatory markers (e.g. cytokines), anti-inflammatory mediators, and oxidative stress indicators (superoxide dismutase and malondialdehyde) were measured before and 24\u2009h after the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the coronary angiography group, patients undergoing PCI who received placebo exhibited concurrent elevations in inflammatory and anti-inflammatory markers at 24\u2009h. Intracoronary adenosine significantly suppressed the rise in the levels of inflammatory markers (e.g. interleukin-6 reduced by 35% vs. placebo) and enhanced anti-inflammatory responses (e.g. interleukin-10 increased by 40% vs. placebo). Following PCI, oxidative stress was evident in placebo-treated patients, as reflected by decreased superoxide dismutase activity (15% reduction) and increased malondialdehyde levels (30% elevation). Adenosine restored superoxide dismutase activity to near-baseline levels and reduced malondialdehyde elevation by 85% compared to placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intracoronary adenosine mitigates PCI-associated systemic inflammation and oxidative stress by rebalancing inflammatory pathways and preserving redox homeostasis. These findings highlight its potential as a therapeutic adjunct for improving clinical outcomes following PCI and warrant further validation in large-scale trials.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration<\/jats:bold>\n                      : Chinese Clinical Trial Registry (ChiCTR); identifier: ChiCTR1800019349.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261416674","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:17:03Z","timestamp":1791800223000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of adenosine on oxidative stress and inflammation in patients with coronary heart disease underlying percutaneous coronary intervention"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7654-5322","authenticated-orcid":false,"given":"Xing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Practice, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2861-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.325596"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002268"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae371"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz301"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.102867"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009503.pub2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009503.pub3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.06.008"},{"issue":"29280","key":"e_1_3_2_11_2","article-title":"Capillary pericytes mediate coronary no-reflow after myocardial ischaemia","volume":"6","author":"O'Farrell FM","year":"2017","unstructured":"O'Farrell FM, Mastitskaya S, Hammond-Haley M, et al. 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