{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:28:39Z","timestamp":1788049719095,"version":"build-2784847793"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although coronavirus disease 2019 and influenza are recognized risk factors for thrombotic conditions, the incidence of acute ischemic stroke following these infections since 2022 remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged \u226565 years with no prior history of stroke, coronavirus disease 2019, or influenza who developed acute ischemic stroke from 3 days before to 28 days after a coronavirus disease 2019 or influenza diagnosis were identified using PCORnet and HealthVerity data collected from 1 January to 31 December 2022. Demographic characteristics, underlying conditions, level of care, outcomes, and acute ischemic stroke incidence were described and compared between patients with early acute ischemic stroke occurring from \u22123 to 7 days from the diagnosis date and late acute ischemic stroke occurring from 8 to 28 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 245,352 patients in PCORnet and 639,396 patients in HealthVerity aged \u226565 years with COVID-19, the incidence of early acute ischemic stroke following coronavirus disease 2019 (PCORnet: 962 per 100,000; HealthVerity: 447 per 100,000) and influenza (PCORnet: 589 per 100,000; HealthVerity: 387 per 100,000) was significantly higher than that of late acute ischemic stroke (coronavirus disease 2019 PCORnet: 81 per 100,000; HealthVerity: 141 per 100,000; influenza PCORnet: 75 per 100,000; HealthVerity: 15 per 100,000) (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although acute ischemic stroke incidence may have declined since 2020\u20132021, the persistent risk of acute ischemic stroke associated with acute coronavirus disease 2019 and influenza underscores the importance of continued monitoring and preventive strategies in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261416675","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:12:32Z","timestamp":1773256352000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute ischemic stroke incidence after influenza or coronavirus disease 2019 among older US adults: A cross-sectional study using electronic health records"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-2107","authenticated-orcid":false,"given":"Emilia H","family":"Koumans","sequence":"first","affiliation":[{"name":"Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Raykin","sequence":"additional","affiliation":[{"name":"Office of Public Health Data, Surveillance and Technology, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Coronado","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Saydah","sequence":"additional","affiliation":[{"name":"Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tegan K","family":"Boehmer","sequence":"additional","affiliation":[{"name":"Office of Public Health Data, Surveillance and Technology, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wiltz","sequence":"additional","affiliation":[{"name":"National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Garg","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E","family":"Desantis","sequence":"additional","affiliation":[{"name":"Office of Public Health Data, Surveillance and Technology, Centers for Disease Control and Prevention, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W","family":"Carton","sequence":"additional","affiliation":[{"name":"Louisiana Public Health Institute, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay G","family":"Cowell","sequence":"additional","affiliation":[{"name":"Peter O\u2019Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, United 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