{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:05:41Z","timestamp":1777727141080,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82105004"],"award-info":[{"award-number":["82105004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis remains a leading cause of mortality in critically ill patients, necessitating the identification of reliable prognostic markers. The triglyceride glucose-body mass index, which combines lipid and glucose metabolism, may serve as a valuable predictor of long-term outcomes in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study employed a retrospective observational cohort design and analyzed data from the MIMIC-IV database encompassing 2424 septic patients admitted between 2008 and 2019. Patients were categorized into quartiles based on triglyceride glucose-body mass index values. The primary outcomes assessed were all-cause mortality rates at 30, 90, and 180 days as well as 1-year post-admission, and analysis was performed using multivariable Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 2424 septic patients meeting the inclusion criteria were finally included in the analyses. Lower triglyceride glucose-body mass index values have been associated with higher long-term mortality outcomes in critically ill septic patients. However, higher triglyceride glucose-body mass index quartiles were associated with a significant reduction in mortality risk at 180 days and 1 year after admission, even after adjustment for potential confounding variables. Patients in the third (hazard ratio: 0.81, 95% confidence interval: 0.67\u20130.98,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.028) and fourth (hazard ratio: 0.73, 95% confidence interval: 0.56\u20130.96,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.026) quartiles exhibited significantly lower hazard ratios for mortality than those in the lowest quartile. Notably, no significant associations were observed with 30-day mortality, suggesting that triglyceride glucose-body mass index values are more strongly associated with long-term outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this retrospective cohort study, lower triglyceride glucose-body mass index values were associated with higher long-term mortality in critically ill septic patients. Our findings suggest that the triglyceride glucose-body mass index serves as a useful prognostic marker and can help identify patients at increased risk of mortality. These results highlight a potential association that warrants further investigation in prospective studies to clarify the role of triglyceride glucose-body mass index in sepsis management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261420914","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:27:55Z","timestamp":1771288075000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between triglyceride glucose-body mass index and all-cause mortality in patients with sepsis: Evidence from a retrospective cohort study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-8535","authenticated-orcid":false,"given":"Yufan","family":"Pu","sequence":"first","affiliation":[{"name":"The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejing","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000461"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67052-3"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02231-0"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66881-6"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-72969-w"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215376"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12499"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05594-1"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01794-8"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab078"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.05.017"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2590115"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01899-x"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04587-3"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2003.s263"},{"key":"e_1_3_7_18_2","unstructured":"Harrell FE. 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