{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:09:54Z","timestamp":1793531394034,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Foundation of Hospital Pharmacy of Zhejiang Pharmaeutical Association","award":["No. 2022ZYY37"],"award-info":[{"award-number":["No. 2022ZYY37"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Sodium\u2013glucose cotransporter 2 inhibitors demonstrate significant cardiovascular benefits in the management of heart failure; however, adverse effects such as urinary tract infection require careful clinical vigilance. This report describes a case of an 80-year-old female patient with heart failure who developed a urinary tract infection and subsequent septic shock following the initiation of dapagliflozin. The patient had been receiving long-term heart failure therapy, with dapagliflozin added 2 months prior to presentation. She presented with fever and developed hypotension (73\/40\u2009mmHg) within 30\u2009min of hospital admission, leading to a diagnosis of septic shock. Management included antimicrobial therapy, vasopressor support, and fluid resuscitation, resulting in hemodynamic stabilization and resolution of the infection. The patient was discharged following clinical improvement. This case underscores the critical importance of vigilant monitoring, proactive patient education, and individualized risk\u2013benefit assessment when prescribing sodium\u2013glucose cotransporter 2 inhibitors to older patients with heart failure who are at high risk. It also provides valuable insights for the development of risk-mitigation strategies.<\/jats:p>","DOI":"10.1177\/03000605261421036","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:06:17Z","timestamp":1772309177000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Septic shock from urinary tract infection associated with sodium\u2013glucose cotransporter 2 inhibitor in a high-risk patient with heart failure: A case report"],"prefix":"10.1177","volume":"54","author":[{"given":"Yantian","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Beilun People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Beilun People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Beilun People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beilun People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People\u2019s Hospital of WenLing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-9729","authenticated-orcid":false,"given":"Meiling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beilun People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1906"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022190"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.05.026"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0315"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12881"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022577"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-223"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199811000-00016"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5443"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15981"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2023.2166485"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00589-9"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-020-01101-4"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2025.14085"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46039-5"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101163"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14633"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6657380"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.33963\/KP.a2021.0172"},{"key":"e_1_3_7_22_2","first-page":"e30552","article-title":"Septic shock due to urinary tract infection in an immunosuppressed patient prescribed dapagliflozin","volume":"14","author":"Suetani Y","year":"2022","unstructured":"Suetani Y, Arita Y, Iida Y, et\u00a0al. Septic shock due to urinary tract infection in an immunosuppressed patient prescribed dapagliflozin. 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