{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:05:52Z","timestamp":1777727152985,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between the cardiometabolic index and the prevalence of endometriosis among reproductive-age women in the United States. This cross-sectional population-based study used data from the National Health and Nutrition Examination Survey (NHANES) 2003\u20132006.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional analysis using data from 1156 women aged 20\u201354 years who participated in NHANES 2003\u20132006. Cardiometabolic index was calculated as the product of the waist-to-height ratio and the triglyceride-to-high-density lipoprotein cholesterol ratio. Logistic regression models adjusted for demographic, reproductive, and lifestyle factors were used to assess the association between cardiometabolic index and self-reported endometriosis. Structural equation modeling was applied to explore potential mediating and moderating effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant inverse association between cardiometabolic index and endometriosis was observed. In the fully adjusted model, each one-unit increment in cardiometabolic index corresponded to a 42% reduction in the odds of self-reported endometriosis (odds ratio\u2009=\u20090.58, 95% confidence interval\u2009=\u20090.38\u20130.91,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Compared with women in the lowest cardiometabolic index quartile, those in the highest quartile exhibited a 51% (precise value: 50.6%) lower prevalence of endometriosis (odds ratio\u2009=\u20090.49, 95% confidence interval\u2009=\u20090.29\u20130.83). Additionally, the use of oral contraceptives significantly moderated the cardiometabolic index\u2013endometriosis relationship\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for interaction &lt;0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiometabolic index is significantly and inversely associated with endometriosis among US women of reproductive age. However, given the cross-sectional design of this study, these findings should be considered preliminary, and causal inferences cannot be drawn.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261422932","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:19:36Z","timestamp":1772079576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inverse association between cardiometabolic index and endometriosis in women of reproductive age: A cross-sectional, population-based study"],"prefix":"10.1177","volume":"54","author":[{"given":"Yanru","family":"Lv","sequence":"first","affiliation":[{"name":"Gynecology Department, The Second People\u2019s Hospital of Liaocheng, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxin","family":"Tang","sequence":"additional","affiliation":[{"name":"Intervention Department, The Second People\u2019s Hospital of Liaocheng, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyang","family":"Su","sequence":"additional","affiliation":[{"name":"Physical Examination Center, Hebei General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9621-4327","authenticated-orcid":false,"given":"Xin","family":"Tian","sequence":"additional","affiliation":[{"name":"Gynecology Department, The Second People\u2019s Hospital of Liaocheng, 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