{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:06:00Z","timestamp":1777727160792,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Special Fund for Science and Technology Plan of Jiangsu Province in 202","award":["BE2023607"],"award-info":[{"award-number":["BE2023607"]}]},{"name":"the Project of Jiangsu Province Hospital of Traditional Chinese Medicine Peak Talent","award":["No.y2021rc36"],"award-info":[{"award-number":["No.y2021rc36"]}]},{"name":"Talent Project established by Chinese Pharmaceutical Association Hospital Phamacy department","award":["CPA-Z05-ZC-2023-003"],"award-info":[{"award-number":["CPA-Z05-ZC-2023-003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the potential of hepatocyte-derived fibrinogen-related protein 1 (HFREP1) as a biomarker for community-acquired pneumonia and community-acquired pneumonia secondary to sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This cross-sectional observational study included 124 patients with community-acquired pneumonia, 52 patients with community-acquired pneumonia\u2013sepsis, and 123 healthy controls. Clinical data were collected, including procalcitonin and C-reactive protein levels. Serum HFREP1 concentrations were measured, and statistical analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>HFREP1 levels differed significantly among the healthy control, community-acquired pneumonia, and community-acquired pneumonia\u2013sepsis groups (37.2\u2009vs. 211.6\u2009vs. 696.8\u2009ng\/mL). Binary logistic regression analysis identified procalcitonin and HFREP1 as independent predictors of community-acquired pneumonia\u2013sepsis, while C-reactive protein was not an independent predictor. The area under the curve for HFREP1 in distinguishing community-acquired pneumonia patients from healthy controls was 0.8810. For differentiating community-acquired pneumonia\u2013sepsis from community-acquired pneumonia, the area under the curves were 0.8814 for HFREP1, 0.8167 for C-reactive protein, and 0.8902 for procalcitonin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HFREP1 may serve as a biomarker for community-acquired pneumonia and community-acquired pneumonia\u2013sepsis. In community-acquired pneumonia\u2013sepsis, HFREP1 was strongly correlated with C-reactive protein and procalcitonin, and its diagnostic performance was comparable to that of procalcitonin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261427147","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:06:17Z","timestamp":1772309177000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of hepatocyte-derived fibrinogen-related protein 1 as a serum biomarker in the diagnosis of community-acquired pneumonia and sepsis: A cross-sectional study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5953-227X","authenticated-orcid":false,"given":"Guoqing","family":"Wang","sequence":"first","affiliation":[{"name":"Pharmacy department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacy department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Pharmacy department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Qian","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Pharmacy department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-4668","authenticated-orcid":false,"given":"Wanjian","family":"Gu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[{"name":"Emergency department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Pharmacy department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002909"},{"key":"e_1_3_7_3_2","volume-title":"Community-acquired pneumonia","author":"Regunath H","year":"2024","unstructured":"Regunath H, Oba Y. 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