{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:06:48Z","timestamp":1777727208365,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Natural Science Foundation of China Youth Program","award":["82102293"],"award-info":[{"award-number":["82102293"]}]},{"name":"Anhui Province Clinical Medical Research Transformation Special Fund","award":["202304295107020040"],"award-info":[{"award-number":["202304295107020040"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370608"],"award-info":[{"award-number":["82370608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hepatitis B virus\u2013related acute-on-chronic liver failure is a rapidly progressive syndrome associated with high mortality. The aim of this study was to develop a dynamic prognostic score for precise outcome prediction in patients with hepatitis B virus\u2013related acute-on-chronic liver failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from a single-center retrospective cohort were used to develop a dynamic prognostic score. The score was subsequently validated in an external multicenter prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 124 patients with hepatitis B virus\u2013related acute-on-chronic liver failure were included in the derivation cohort. The change in the delta Chinese Severe Hepatitis B Research Group-acute-on-chronic liver failure II score between day 7 and baseline (\u03b4COSSH-ACLF II 7-0) showed better predictive performance than the baseline Chinese Severe Hepatitis B Research Group-acute-on-chronic liver failure II score. Multivariate Cox regression analysis identified baseline total bilirubin, baseline prothrombin time international normalized ratio, and \u03b4COSSH-ACLF II 7-0 as independent predictors of 90-day survival. We proposed a dynamic prognostic score calculated as follows: Dynamic prognostic score\u2009=\u20090.005\u2009\u00d7\u2009total bilirubin\u2009+\u20090.609\u2009\u00d7\u2009prothrombin time international normalized ratio\u2009+\u20091.234\u2009\u00d7\u2009\u03b4COSSH ACLF II 7-0. The area under the curves of the new score were 0.923 and 0.925 for predicting 28- and 90-day mortality, respectively. These findings were replicated in the validation cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The new prognostic score, based on dynamic changes in the clinical course, can accurately predict short-term mortality in patients with hepatitis B virus\u2013elated acute-on-chronic liver failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261429829","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:39:33Z","timestamp":1774589973000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a dynamic prognostic score for hepatitis B virus\u2013related acute-on-chronic liver failure"],"prefix":"10.1177","volume":"54","author":[{"given":"Jiemenglu","family":"Li","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6514-0069","authenticated-orcid":false,"given":"Qingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical 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