{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:06:46Z","timestamp":1777727206255,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Research of Medical Innovation and Application, Science and Technology Development Project of Suzhou City","award":["SKY2023109"],"award-info":[{"award-number":["SKY2023109"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["82073180"],"award-info":[{"award-number":["82073180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Education Promoting Health for Young Scholar, Science and Technology Project of Suzhou City","award":["KJXW2021086"],"award-info":[{"award-number":["KJXW2021086"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the potential involvement of PANoptosis-related genes in gastric cancer susceptibility through multiomics analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Summary-data\u2013based Mendelian randomization was performed by integrating blood-derived methylation, gene expression, and protein quantitative trait loci data with genome-wide association study results. The findings were further evaluated in The Cancer Genome Atlas cohort, followed by protein\u2013protein interaction analysis, drug prediction, and molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Summary-data\u2013based Mendelian randomization and colocalization analyses identified several traits suggestively associated with gastric cancer risk. Genetically predicted higher expression of apoptosis and caspase activation inhibitor (\n                      <jats:italic toggle=\"yes\">AVEN<\/jats:italic>\n                      ) and hepatocyte growth factor (\n                      <jats:italic toggle=\"yes\">HGF<\/jats:italic>\n                      ) as well as higher HGF protein levels were associated with increased risk, whereas higher levels of protein phosphatase 2 regulatory subunit B beta (PPP2R2B) appeared to be protective. Multiomics integration suggested epigenetic regulation of\n                      <jats:italic toggle=\"yes\">HGF<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">PPP2R2B<\/jats:italic>\n                      . The Cancer Genome Atlas analysis corroborated the dysregulation of these candidates, with high\n                      <jats:italic toggle=\"yes\">AVEN<\/jats:italic>\n                      expression associated with poorer survival. Protein\u2013protein interaction and drug prediction analyses highlighted functional networks and potential therapeutics, supported by molecular docking demonstrating strong HGF\n                      <jats:italic toggle=\"yes\">-<\/jats:italic>\n                      binding affinities. However, these associations did not reach statistical significance in the independent validation cohort, possibly due to limited statistical power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study identified\n                      <jats:italic toggle=\"yes\">AVEN<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">HGF<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">PPP2R2B<\/jats:italic>\n                      as potential candidate genes for gastric cancer. These findings require further validation in larger cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261430163","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:17:11Z","timestamp":1773724631000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A multiomics Mendelian randomization study on PANoptosis-related genes and gastric cancer risk"],"prefix":"10.1177","volume":"54","author":[{"given":"Yunliang","family":"Wang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujian","family":"Xia","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Suzhou Wuzhong Hospital of Traditional Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzi","family":"Meng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4053-3325","authenticated-orcid":false,"given":"Xinguo","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26844"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2024.100845"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03921-1"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2021.03.005"},{"key":"e_1_3_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2021.03.001"},{"key":"e_1_3_10_7_2","first-page":"166","article-title":"[Application and progress of convolutional neural network-based pathological diagnosis of gastric cancer]","volume":"52","author":"Guo XM","year":"2021","unstructured":"Guo XM, Zhao HY, Shi ZY, et\u00a0al. 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