{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T08:03:13Z","timestamp":1780128193809,"version":"3.54.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In this study we investigated the effect of adding dexmedetomidine to fascia iliaca compartment block on postoperative analgesia in patients undergoing femoral fracture surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this double-blind randomized clinical trial study, 70 patients aged 20\u201375 years, classified as American Society of Anesthesiologists physical status I and II who were scheduled to undergo femoral fracture surgery under spinal anesthesia were included. Patients were divided into intervention and control groups using the block randomization method (35 patients in each group). In the intervention group, fascia iliaca block was performed using 20\u2009cc of 0.25% bupivacaine with 0.5\u2009cc of 50 \u03bcg dexmedetomidine (fascia iliaca compartment block\u2009+\u2009dexmedetomidine group), and in the control group, the block was performed using 20\u2009cc of 0.25% bupivacaine alone (fascia iliaca block group). The outcomes, including the average time to achieve sensory block, analgesia duration, number of times rescue analgesia was needed, time to first rescue analgesia, and pain severity assessed using the visual analog scale within 24\u2009h postoperatively, were measured and compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The demographic data and time to reach sensory block were not significantly different between the two groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The mean analgesia duration in the fascia iliaca compartment block\u2009+\u2009dexmedetomidine group was significantly longer than that in the fascia iliaca block group (11.42\u2009\u00b1\u20091.65 vs. 9.26\u2009\u00b1\u20091.39\u2009h;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). An analgesic was prescribed for 11.4% and 31.4% of the patients 2\u20136\u2009h postoperatively and for 54.3% and 77.1% at 6\u201312\u2009h postoperatively in the fascia iliaca compartment block\u2009+\u2009dexmedetomidine and fascia iliaca block groups, respectively, representing a statistically significant difference between the two groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03). The visual analogue scale scores while in recovery, at 2\u2009h postoperatively, and at 12\u201324\u2009h postoperatively did not show a statistically significant difference between the two groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05); however, patients in the fascia iliaca compartment block group had significantly higher pain scores than those in the fascia iliaca compartment block\u2009+\u2009dexmedetomidine group at 2\u20136\u2009h and 6\u201312\u2009h postoperatively (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Addition of dexmedetomidine to bupivacaine in the fascia iliaca block in femoral fracture surgeries reduces the severity of postoperative pain and need for analgesics and increases the analgesia duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261431479","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:02:29Z","timestamp":1779872549000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of adding dexmedetomidine to fascia iliaca compartment block on postoperative analgesia in patients undergoing femoral fractures surgery: A randomized double-blind clinical trial"],"prefix":"10.1177","volume":"54","author":[{"given":"Nazli","family":"Karami","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohid","family":"Karami","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Taleb","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Ghodratizadeh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_3_8_2_2","first-page":"55","article-title":"Efficacy of adding dexmedetomidine in fascia iliaca compartment block to provide analgesia for positioning femur fracture patients before spinal anesthesia","volume":"1","author":"Amin M","year":"2020","unstructured":"Amin M, Abdalla AM, Soltan SA. 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