{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:07:53Z","timestamp":1777727273233,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High-sensitivity C-reactive protein, a key inflammatory biomarker, can indicate the risk of cardiovascular diseases. The cardiometabolic index has been associated with metabolic and cardiovascular outcomes; however, its direct relationship with high-sensitivity C-reactive protein remains unclear. This study aimed to explore this association and identify influencing factors in adult population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study used data from the 2015\u20132018 National Health and Nutrition Examination Survey. A multivariate logistic regression model was applied to assess the association between cardiometabolic index and high-sensitivity C-reactive protein levels (&gt;3.0\u2009mg\/L) in 3970 adults, with adjustment for demographic characteristics, comorbidities, and lifestyle factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cardiometabolic index was independently associated with high-risk high-sensitivity C-reactive protein (adjusted odds ratio\u2009=\u20091.11, 95% confidence interval: 1.03\u20131.19, p\u2009=\u20090.007). Subgroup analyses indicated that the association was more pronounced in females and non-Hispanic Black participants (p values for interaction were &lt;0.001 and 0.004, respectively). Restricted cubic spline curves confirmed a nonlinear relationship between cardiometabolic index and high-risk high-sensitivity C-reactive protein (nonlinearity p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cardiometabolic index demonstrated a significant positive association with high-risk high-sensitivity C-reactive protein in US adults, serving as a marker linking cardiometabolic status to chronic inflammation. Further studies are needed to validate causality and explore cardiometabolic index\u2013guided prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261436654","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:17:44Z","timestamp":1775870264000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between cardiometabolic index and high-sensitivity C-reactive protein: A cross-sectional study from National Health and Nutrition Examination Survey 2015 to 2018"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8332-5263","authenticated-orcid":false,"given":"Yuhao","family":"Yan","sequence":"first","affiliation":[{"name":"The Second Hospital of Nanjing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-768X","authenticated-orcid":false,"given":"Yong","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Nanjing"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1425168"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14666"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2024.118532"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107873"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-025-02430-y"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2022.03.008"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2023.11.009"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.12.006"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00215-5"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.40307"},{"key":"e_1_3_7_12_2","first-page":"439","article-title":"High-sensitivity C-reactive protein: clinical importance","volume":"29","author":"Bassuk SS","year":"2004","unstructured":"Bassuk SS, Rifai N, Ridker PM. 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