{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:45:06Z","timestamp":1777945506471,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"open Project of Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention","award":["GXXNXG202401"],"award-info":[{"award-number":["GXXNXG202401"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82472220"],"award-info":[{"award-number":["82472220"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010267 and 2024A1515010073"],"award-info":[{"award-number":["2023A1515010267 and 2024A1515010073"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to explore the influence of the angiotensin-(1\u20137)\/Mas receptor and angiotensin II\/angiotensin II type 1 receptor pathways on pyroptosis during sepsis and their subsequent effects on cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult C57BL\/6 mice were subjected to cecal ligation and puncture to induce sepsis. Brain microvascular endothelial cells were treated with angiotensin II and angiotensin-(1\u20137) to evaluate their impact on pyroptotic processes. Cognitive performance was assessed using the Morris water maze method, and blood\u2013brain barrier permeability was quantified using Evans blue staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the sham group, sepsis induced sustained activation of the angiotensin II\/angiotensin II type 1 receptor pathway, whereas the angiotensin-(1\u20137)\/Mas receptor pathway was progressively suppressed. Genetic ablation of cysteine-dependent aspartate protease-1 significantly attenuated pyroptosis in brain endothelial cells, decreased blood\u2013brain barrier permeability, and enhanced cognitive function in septic mice compared with that in the cecal ligation and puncture group. Angiotensin-(1\u20137) treatment improved cognitive function in septic mice and significantly suppressed angiotensin II-induced pyroptosis, with these effects reversed by the Mas receptor antagonist A-779.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identified a novel mechanism in which angiotensin-(1\u20137) selectively suppresses angiotensin II-induced pyroptosis in brain endothelial cells, consequently ameliorating cognitive deficits during sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261437974","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:32:50Z","timestamp":1777512770000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin-(1\u20137) suppresses pyroptosis in cerebral endothelium to decrease blood\u2013brain barrier permeability and cognitive impairments in sepsis"],"prefix":"10.1177","volume":"54","author":[{"given":"Yongli","family":"Han","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-5684","authenticated-orcid":false,"given":"Hongguang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yirun","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shantou University Medical 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