{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:08:06Z","timestamp":1777727286493,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence suggests that elevated serum uric acid levels may be associated with adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between serum uric acid levels and adverse pregnancy outcomes among pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted among 200 pregnant women attending Vinh Long General Hospital, including 100 women with hyperuricemia and 100 without hyperuricemia. Hyperuricemia was defined as a serum uric acid level &gt;360\u2009\u00b5mol\/L. Pregnancy-, delivery-, and postpartum-related complications were recorded and compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean maternal age was 25.06\u2009\u00b1\u20095.79 years. In the hyperuricemia group, 45.0% were primigravida, whereas 22.0% had multiple pregnancies. Adverse pregnancy outcomes were more frequent in women with hyperuricemia than in those without hyperuricemia (28.0% vs. 15.0%; odds ratio\u2009=\u20092.20; 95% confidence interval: 1.09\u20134.44). Within the hyperuricemia group, smoking was more common among women who developed complications than among those without complications (42.9% vs. 18.1%), along with lower platelet counts and higher creatinine levels (p\u2009&lt;\u20090.05). Multivariable logistic regression analysis identified alcohol consumption (odds ratio\u2009=\u20093.85), serum creatinine (odds ratio\u2009=\u20091.19), and hyperuricemia (odds ratio\u2009=\u20091.65) as independent predictors of adverse pregnancy outcomes (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hyperuricemia was independently associated with an increased risk of adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261438920","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:35:13Z","timestamp":1776310513000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between serum uric acid levels and adverse pregnancy outcomes: A prospective cohort study"],"prefix":"10.1177","volume":"54","author":[{"given":"Hang Thi Thu","family":"Ho","sequence":"first","affiliation":[{"name":"Vinh Long Department of Health, Vietnam"},{"name":"Can Tho University of Medicine and Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dung My","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Vinh Long General Hospital, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Van Lang University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam Phan Hai","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Can Tho University of Medicine and Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4441-8173","authenticated-orcid":false,"given":"Ha Hong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Can Tho University of Medicine and Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19074080"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-015-0291-x"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.ceog5112259"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01115-8"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13865"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.07.042"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2231101"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.63907"},{"key":"e_1_3_7_11_2","first-page":"e48230","article-title":"The history and faults of the body mass index and where to look next: a literature review","volume":"15","author":"Pray R","year":"2023","unstructured":"Pray R, , andRiskin S. The history and faults of the body mass index and where to look next: a literature review. 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Serum uric acid levels as a risk stratification tool in hypertensive disorders of pregnancy: a retrospective study. 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