{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:16:51Z","timestamp":1777943811833,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Guangxi Science and Technology Program","award":["GK AB25069088"],"award-info":[{"award-number":["GK AB25069088"]}]},{"name":"Guangxi Colleges and Universities Key Laboratory of Biological Targeted Diagnosis and Treatment","award":["GXSWBX201501"],"award-info":[{"award-number":["GXSWBX201501"]}]},{"name":"\"139\" Program Training Project for the Cultivation of High-level and Key Talent in Guangxi Medicine","award":["G201903036"],"award-info":[{"award-number":["G201903036"]}]},{"name":"Open Project of Key Laboratory of Biomolecular Medicine Research in Guangxi Medical University","award":["GXBMR201605"],"award-info":[{"award-number":["GXBMR201605"]}]},{"name":"Guangxi Medical & Health Appropriate Technology Development and Promotion Application Project","award":["S2019052"],"award-info":[{"award-number":["S2019052"]}]},{"name":"General Project of Guangxi Natural Science Foundation","award":["2018GXNSFAA138061, 2025GXNSFAA069760"],"award-info":[{"award-number":["2018GXNSFAA138061, 2025GXNSFAA069760"]}]},{"name":"Nanning Scientific Research and Technology Development Project","award":["20183203-3"],"award-info":[{"award-number":["20183203-3"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560548, 82360587, 32260241,82360587"],"award-info":[{"award-number":["82560548, 82360587, 32260241,82360587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Projects of Guangxi Natural Science Foundation","award":["2024GXNSFDA010022"],"award-info":[{"award-number":["2024GXNSFDA010022"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate an integrated prognostic model based on tumor immune microenvironmental, systemic inflammatory, and coagulation markers to improve prognostic stratification and personalize management for bladder cancer patients undergoing surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 140 patients who underwent radical or partial cystectomy at our institution between 2013 and 2021. Cutoff values for continuous variables were determined using receiver operating characteristic analysis. Independent prognostic factors for overall survival were identified using univariate and multivariate Cox regression analyses. A nomogram was subsequently developed and validated using time-dependent receiver operating characteristic curves, calibration plots, and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis confirmed that tertiary lymphoid structure density, hemoglobin level, D-dimer level, platelet-to-lymphocyte ratio, and clinical stage are independent predictors of overall survival. The constructed nomogram demonstrated high predictive accuracy for 1-, 3-, and 5-year overall survivals, with area under the curve values of 0.868, 0.880, and 0.894, respectively. Calibration and decision curve analyses confirmed the model\u2019s excellent consistency and clinical utility. Risk stratification based on the nomogram revealed significant survival differences between the groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed and validated a novel nomogram that integrates multidimensional immune microenvironmental, systemic inflammatory, and coagulation biomarkers. This model provides a practical tool for prognostic assessment and risk stratification in bladder cancer patients following surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261441388","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:16:58Z","timestamp":1777439818000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A multidimensional nomogram integrating immune, inflammatory, and coagulation markers for personalized prognosis in bladder cancer"],"prefix":"10.1177","volume":"54","author":[{"given":"Yongpeng","family":"Li","sequence":"first","affiliation":[{"name":"Guangxi Medical University Cancer Hospital, China"},{"name":"Guangxi Clinical Research Center for Bladder Cancer, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Cancer Hospital, China"},{"name":"Guangxi Clinical Research Center for Bladder Cancer, China"},{"name":"University Engineering Research Center of Oncolytic &amp; Nanosystem Development, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-7202","authenticated-orcid":false,"given":"Chanzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Cancer Hospital, China"},{"name":"Guangxi Clinical Research Center for Bladder Cancer, China"},{"name":"University Engineering Research Center of Oncolytic &amp; Nanosystem Development, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangxi Clinical Research Center for Bladder Cancer, China"},{"name":"University Engineering Research Center of Oncolytic &amp; Nanosystem Development, China"},{"name":"Department of Urology, Guangxi Medical University Cancer Hospital, China"},{"name":"Guangxi Key Laboratory of Extremely Weak Magnetic Field in Cancer Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongchao","family":"Chen","sequence":"additional","affiliation":[{"name":"Red Cross Hospital of Yulin City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengming","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Cancer Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youzhi","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Cancer Hospital, China"},{"name":"University Engineering Research Center of Oncolytic &amp; Nanosystem Development, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadong","family":"Xie","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Guangxi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjie","family":"Ban","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianlin","family":"Yi","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei province, Tongji Medical College, Huazhong University of Science and Technology China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Cancer Hospital, China"},{"name":"Guangxi Clinical Research Center for Bladder Cancer, China"},{"name":"University Engineering Research Center of Oncolytic &amp; Nanosystem Development, China"},{"name":"Department of Urology, Guangxi Medical University Cancer Hospital, China"},{"name":"Guangxi Key Laboratory of Extremely Weak Magnetic Field in Cancer Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.01.018"},{"key":"e_1_3_10_4_2","first-page":"859","article-title":"Usefulness of the Memorial Sloan Kettering Cancer Center nomogram in the prognosis of patients treated with radical cystectomy for invasive bladder cancer","volume":"66","author":"Molina Escudero R","year":"2013","unstructured":"Molina Escudero R, Herranz Amo F, Monzo Gardiner J, et\u00a0al. 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