{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:27:31Z","timestamp":1792189651697,"version":"4.4.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Regional Science Fund Project of the National Natural Science Foundation of China","award":["No. 32460305"],"award-info":[{"award-number":["No. 32460305"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the mediating role of serum lipids in the association between dietary fiber intake and gallstones prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed the data from 4896 adults participating in the National Health and Nutrition Examination Survey conducted between 2017\u2013March 2020 and August 2021\u2013August 2023. Logistic regression models and subgroup analyses were conducted to assess the correlation between dietary fiber intake and gallstone prevalence. Additionally, smooth curve fitting based on the generalized additive model was applied to elucidate nonlinear relationships. The mediating effects of lipid-related indicators, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, total cholesterol, non-high-density lipoprotein cholesterol, residual cholesterol, and atherogenic index of plasma were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High-density lipoprotein cholesterol and atherogenic index of plasma significantly mediated the association between dietary fiber intake and gallstone prevalence, with mediation proportions of 5.06% and 4.26%, respectively (all\n                      <jats:italic toggle=\"yes\">p\u2009<\/jats:italic>\n                      &lt;\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      0.05). Conversely, the mediating effects of other lipid parameters (non-high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and residual cholesterol) were not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There exists a complex relationship between dietary fiber intake, serum lipid levels, and gallstone formation, with serum lipids potentially serving as mediators. Future research should explore this mechanism in greater depth to offer new insights for the prevention and treatment of gallstones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261451085","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:24:35Z","timestamp":1781832275000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dietary fiber intake and gallstones: The mediating role of serum lipids"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3545-0425","authenticated-orcid":false,"given":"Wenli","family":"Jiang","sequence":"first","affiliation":[{"name":"Lanzhou University"},{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furui","family":"Wang","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Lanzhou University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-023-03355-z"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32978"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4007"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-016-0529-6"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2015.09.003"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01917G"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2020.12.001"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-018-0407-1"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2061909"},{"key":"e_1_3_8_11_2","first-page":"266","article-title":"Effects of fiber administration in the prevention of gallstones in obese patients on a reducing diet. 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