{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:20:43Z","timestamp":1783012843788,"version":"3.54.6"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe nationwide mortality patterns related to Alzheimer's disease and cerebrovascular disease in United States adults aged \u226565\u2009years and explore future trend projections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we utilized the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research database (ICD-10 G30, I60\u2013I69) to calculate crude and age-adjusted mortality rates per 100,000 population. Temporal trends were modeled using Joinpoint regression, and 10-year forecasts were obtained using autoregressive integrated moving average models. Subgroup analyses were performed by sex, race\/ethnicity, census region, urbanization, and place of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 199,606 Alzheimer's disease\u2013cardiovascular disease-related deaths. Overall, age-adjusted mortality rates peaked at 24.8 in 2002, reduced to 14.2 in 2013, and then rose to 18.7 in 2020 before dropping to 16.6 in 2023. Women exhibited higher age-adjusted mortality rates than men (20.1 vs. 16.0). Individuals of White and Black ethnicity bore the greatest burden, and the South and West recorded the highest regional age-adjusted mortality rates. These rates were consistently higher in non-metropolitan areas than in metropolitan areas. Exploratory projections estimate an overall age-adjusted mortality rate of 16.6 by 2033, with persistently higher rates in women, non-Hispanic Black populations, and among those residing in the West and non-metropolitan areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite substantial decline since the early 2000s, Alzheimer's disease\u2013cardiovascular disease mortality remains high and unevenly distributed. Exploratory projections suggest that the burden will remain substantial, underscoring the need for targeted prevention, vascular risk reduction, and equity-focused dementia care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261454837","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:13:47Z","timestamp":1782850427000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nationwide trends and forecasts in Alzheimer's and cerebrovascular disease-related mortality in the United States, 1999\u20132023: A CDC WONDER analysis"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8015-033X","authenticated-orcid":false,"given":"Ali Shan","family":"Hafeez","sequence":"first","affiliation":[{"name":"CMH Multan Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2660-3147","authenticated-orcid":false,"given":"Saira","family":"Mumtaz","sequence":"additional","affiliation":[{"name":"CMH Multan Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6978-5080","authenticated-orcid":false,"given":"Laksh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubashara","family":"Amir","sequence":"additional","affiliation":[{"name":"Faisalabad Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5316-2329","authenticated-orcid":false,"given":"Rick","family":"Maity","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Kharagpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1584-3924","authenticated-orcid":false,"given":"Aamir","family":"Khan","sequence":"additional","affiliation":[{"name":"Khyber Teaching Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7389-6998","authenticated-orcid":false,"given":"Muhammad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Allama Iqbal Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0735-6202","authenticated-orcid":false,"given":"Asad","family":"Zaman","sequence":"additional","affiliation":[{"name":"CMH Multan Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Asad","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-6293","authenticated-orcid":false,"given":"Pramod","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Barhabise Primary Health Care Centre, Sindhupalchowk, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rafae","family":"Faisal","sequence":"additional","affiliation":[{"name":"CMH Multan Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2569","authenticated-orcid":false,"given":"Arkadeep","family":"Dhali","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust"},{"name":"The University of Sheffield"},{"name":"The University of Edinburgh"},{"name":"Imperial College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization. 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