{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:53:21Z","timestamp":1781758401021,"version":"3.54.5"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Multisystem Inflammatory Syndrome in Children is a serious complication associated with coronavirus disease 2019 that commonly affects individuals under 19 years of age. This condition can present with a wide spectrum of clinical manifestations, some of which may be severe or life-threatening. Management can be challenging due to the variability in clinical presentation and response to therapy. This report describes the case of a toddler with no previously documented severe acute respiratory syndrome coronavirus 2 infection who presented with a 30-day relapsing fever that demonstrated partial response to antipyretics and was associated with gastrointestinal symptoms and a skin rash. Following extensive clinical and laboratory investigations, the patient was diagnosed with multisystem inflammatory syndrome in children and was successfully treated with intravenous immunoglobulin and corticosteroids.<\/jats:p>","DOI":"10.1177\/03000605261455136","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:19:26Z","timestamp":1781569166000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypical multisystem inflammatory syndrome in children presenting with 1-month persistent fever in a 17-month-old: A case report"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4616-7677","authenticated-orcid":false,"given":"Mohammad Noor","family":"Katranjy","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Hama University, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6827-485X","authenticated-orcid":false,"given":"Ahmad","family":"Alabdlilrazzak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hama University, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6720-766X","authenticated-orcid":false,"given":"Mohamad","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hama University, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0216-8796","authenticated-orcid":false,"given":"Abd Alrhman","family":"Alras","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hama University, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghalia","family":"Warrar","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Hama Maternity and Children\u2019s Hospital, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras","family":"Alharroush","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Hama Maternity and Children\u2019s Hospital, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021756"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piab007"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_3_6_5_2","article-title":"Multisystem inflammatory syndrome in children: IAP guidelines","author":"Sadaf A","year":"2023","unstructured":"Sadaf A, Kohli KK. Multisystem inflammatory syndrome in children: IAP guidelines. Medical Dialogues 2023.","journal-title":"Medical Dialogues"},{"key":"e_1_3_6_6_2","unstructured":"Son MBF Friedman K. COVID-19: multisystem inflammatory syndrome in children (MIS-C) clinical features evaluation and diagnosis. In: UpToDate. Waltham (MA): Wolters Kluwer (updated 07 March 2023; cited 06 November 2025)."},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.016"},{"key":"e_1_3_6_8_2","first-page":"108","article-title":"Multisystem inflammatory syndrome in children with COVID-19: diagnosis and acute care management","volume":"33","author":"GottliebM WT","year":"2021","unstructured":"GottliebM WT, Maddox R. Multisystem inflammatory syndrome in children with COVID-19: diagnosis and acute care management. Curr Opin Pediatr 2021; 33: 108\u2013116.","journal-title":"Curr Opin Pediatr"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1551122"},{"key":"e_1_3_6_10_2","first-page":"e40776","article-title":"Multisystem inflammatory syndrome: a case in an adult with controlled lymphoma and a persistent SARS-CoV-2 infection","volume":"15","author":"Pipit\u00f2 L","year":"2023","unstructured":"Pipit\u00f2 L, Medaglia A, Russotto I, et\u00a0al. Multisystem inflammatory syndrome: a case in an adult with controlled lymphoma and a persistent SARS-CoV-2 infection. Cureus 2023; 15: e40776.","journal-title":"Cureus"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13237177"},{"key":"e_1_3_6_12_2","unstructured":"UC Davis Health Department of Pediatrics. Guidelines for Treatment of Multisystem Inflammatory Syndrome in Children Following COVID-19 infection (MIS-C) [Internet]. 2023 Feb."}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261455136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261455136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261455136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:16:29Z","timestamp":1781756189000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261455136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/03000605261455136"],"URL":"https:\/\/doi.org\/10.1177\/03000605261455136","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"article-number":"03000605261455136"}}