{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T22:47:43Z","timestamp":1782082063365,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association of preoperative hypoalbuminemia (serum albumin &lt;35\u2009g\/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct a nomogram based on prognostically relevant clinicopathological variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients with gastric cancer who underwent radical gastrectomy. Clinicopathological variables and survival outcomes were compared between groups. Univariate and multivariable analyses were performed to identify variables associated with prognosis, and a nomogram was constructed based on significant predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preoperative hypoalbuminemia was significantly associated with adverse clinicopathological characteristics, including anemia, lymphocyte depletion, advanced American Joint Committee on Cancer stage, vascular invasion, and perineural invasion. Kaplan\u2013Meier analysis showed that hypoalbuminemia was associated with poorer overall survival. In multivariable Cox regression analysis, lymph node metastasis remained independently associated with overall survival, whereas preoperative hypoalbuminemia was not an independent prognostic factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative hypoalbuminemia may reflect unfavorable nutritional and inflammatory status and was associated with adverse clinicopathological characteristics and poorer survival in univariate analysis. However, it was not independently associated with overall survival after multivariable adjustment. Lymph node metastasis remained an independent prognostic factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261457301","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:13:46Z","timestamp":1781849626000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative hypoalbuminemia as a prognostic factor in patients with gastric cancer undergoing radical gastrectomy: Construction of a nomogram"],"prefix":"10.1177","volume":"54","author":[{"given":"Zhen-Wu","family":"Qu","sequence":"first","affiliation":[{"name":"Department of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-3527","authenticated-orcid":false,"given":"Ming-Yue","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001474"},{"key":"e_1_3_10_3_2","first-page":"456","article-title":"Impact of preoperative nutritional status based on albumin and body mass index on long-term survival in patients with gastric cancer","volume":"17","author":"Wang Z","year":"2025","unstructured":"Wang Z, Liu Y, Zhang X, et\u00a0al. Impact of preoperative nutritional status based on albumin and body mass index on long-term survival in patients with gastric cancer. World J Gastrointest Surg 2025; 17: 456\u2013465.","journal-title":"World J Gastrointest Surg"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1472"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_3_10_6_2","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v11.i1.17"},{"key":"e_1_3_10_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01715-z"},{"key":"e_1_3_10_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1007176"},{"key":"e_1_3_10_9_2","first-page":"215","article-title":"Construction and validation of a prognostic nomogram for gastric cancer patients with distant metastasis","volume":"17","author":"Liu X","year":"2025","unstructured":"Liu X, Zhang Y, Chen L. Construction and validation of a prognostic nomogram for gastric cancer patients with distant metastasis. World J Gastrointest Surg 2025; 17: 215\u2013226.","journal-title":"World J Gastrointest Surg"},{"key":"e_1_3_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_10_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947802"},{"key":"e_1_3_10_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1492041"},{"key":"e_1_3_10_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1624602"},{"key":"e_1_3_10_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1530522"},{"key":"e_1_3_10_15_2","first-page":"15181","article-title":"Usefulness of the preoperative Prognostic Immune and Nutritional Index as a prognostic predictor for patients with gastric cancer","volume":"29","author":"Hamasaki M","year":"2025","unstructured":"Hamasaki M, Yamashita Y, Hoshino S, et\u00a0al. Usefulness of the preoperative Prognostic Immune and Nutritional Index as a prognostic predictor for patients with gastric cancer. Oncol Lett 2025; 29: 15181.","journal-title":"Oncol Lett"},{"key":"e_1_3_10_16_2","first-page":"620","article-title":"Preoperative albumin level is a prognostic factor in patients with gastric cancer","volume":"23","author":"Kanda M","year":"2016","unstructured":"Kanda M, Tanaka C, Kobayashi D, et\u00a0al. Preoperative albumin level is a prognostic factor in patients with gastric cancer. Ann Surg Oncol 2016; 23: 620\u2013627.","journal-title":"Ann Surg Oncol"},{"key":"e_1_3_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.03.031"},{"key":"e_1_3_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"e_1_3_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2025.08.029"},{"key":"e_1_3_10_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-022-01331-8"},{"key":"e_1_3_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31288-5"},{"key":"e_1_3_10_22_2","first-page":"512","article-title":"Preoperative hypoalbuminemia as a prognostic factor in gastric cancer patients undergoing gastrectomy: a large-scale cohort study","volume":"25","author":"Kim Y","year":"2022","unstructured":"Kim Y, Kwon O, Oh ST, et\u00a0al. Preoperative hypoalbuminemia as a prognostic factor in gastric cancer patients undergoing gastrectomy: a large-scale cohort study. Gastric Cancer 2022; 25: 512\u2013521.","journal-title":"Gastric Cancer"},{"key":"e_1_3_10_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15182284"},{"key":"e_1_3_10_24_2","first-page":"995","article-title":"The impact of the COVID-19 pandemic on gastric cancer stage and nutritional status","volume":"8","author":"G\u00fcl MC","year":"2025","unstructured":"G\u00fcl MC, Haf\u0131zo\u011flu E. The impact of the COVID-19 pandemic on gastric cancer stage and nutritional status. 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