{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:52:57Z","timestamp":1781851977375,"version":"3.54.5"},"reference-count":47,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023206327"],"award-info":[{"award-number":["H2023206327"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Studies have indicated that combining\n                      <jats:italic toggle=\"yes\">Maackia amurensis<\/jats:italic>\n                      seed lectin with first-line chemotherapeutic agents enhances the efficacy of treatment for oral squamous cell carcinoma. The study aimed to investigate the underlying mechanism of\n                      <jats:italic toggle=\"yes\">Maackia amurensis<\/jats:italic>\n                      seed lectin in the treatment of oral squamous cell carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Gene Expression Omnibus dataset mining, reverse transcription\u2013quantitative polymerase chain reaction, and western blot analysis were performed to identify the expression of SRY-box transcription factor 2, methyltransferase 3, and YTH domain-containing protein 1 in oral squamous cell carcinoma. The N6-methyladenosine methylation levels of SRY-box transcription factor 2 were detected though methylated RNA immunoprecipitation. The effects of\n                      <jats:italic toggle=\"yes\">Maackia amurensis<\/jats:italic>\n                      seed lectin and SRY-box transcription factor 2 on oral squamous cell carcinoma cells were determined via Cell Counting Kit-8 and colony formation assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results demonstrated that increased expression of SRY-box transcription factor 2 in oral squamous cell carcinoma is correlated with elevated levels of N6-methyladenosine modification, and treatment with\n                      <jats:italic toggle=\"yes\">Maackia amurensis<\/jats:italic>\n                      seed lectin reduces the N6-methyladenosine modification level and SRY-box transcription factor 2 expression. Moreover, overexpression of SRY-box transcription factor 2 reversed the inhibitory effects of\n                      <jats:italic toggle=\"yes\">Maackia amurensis<\/jats:italic>\n                      seed lectin on oral squamous cell carcinoma cell proliferation and colony formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Maackia amurensis<\/jats:italic>\n                      seed lectin may inhibit oral squamous cell carcinoma cell proliferation by suppressing N6-methyladenosine modification\u2013mediated SRY-box transcription factor 2 expression, thereby improving chemotherapy sensitivity in oral squamous cell carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261457780","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:52:04Z","timestamp":1781671924000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Maackia amurensis<\/i>\n                    seed lectin inhibits oral squamous cell carcinoma tumorigenesis by suppressing N6-methyladenosine  modification\u2013mediated  SRY-box transcription factor 2 expression"],"prefix":"10.1177","volume":"54","author":[{"given":"Yong","family":"Du","sequence":"first","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-3000","authenticated-orcid":false,"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongguang","family":"Lian","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The Second Hospital of Hebei Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104799"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-023-00249-w"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2023.105841"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041845"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408390591034445"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021650"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108466"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07759-6"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-025-06265-z"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03456-8"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.03.004"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.01.008"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.08.007"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1518"},{"key":"e_1_3_7_16_2","first-page":"e52265","article-title":"A preliminary study of the role of endothelial-mesenchymal transitory factor SOX 2 and CD147 in the microvascularization of oral squamous cell carcinoma","volume":"16","author":"Zisis V","year":"2024","unstructured":"Zisis V, Anastasiadou PA, Poulopoulos A, et\u00a0al. 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