{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T22:47:41Z","timestamp":1782082061834,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nantong Municipal Health Commission Scientific Research Project","award":["MSZ2025098"],"award-info":[{"award-number":["MSZ2025098"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the predictive performance of quick Sequential Organ Failure Assessment, National Early Warning Score 2, Shock Index, and Modified Shock Index for in-hospital mortality in adult emergency department patients with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included 187 adult patients who presented to the emergency department and met the Sepsis-3 definition of sepsis between January 2022 and December 2023. The predictive performance of quick Sequential Organ Failure Assessment, National Early Warning Score 2, Shock Index, and Modified Shock Index was evaluated using receiver operating characteristic curve analysis, DeLong\u2019s test, and diagnostic performance metrics, including sensitivity, specificity, positive predictive value, and negative predictive value. Multivariable logistic regression was performed as an exploratory secondary analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 187 patients, 37 (19.8%) died during hospitalization. Non-survivors showed greater physiological derangement at emergency department presentation, including higher respiratory rate, heart rate, and lactate levels and lower oxygen saturation. National Early Warning Score 2 demonstrated the highest discriminatory performance for in-hospital mortality (area under the curve, 0.94), followed by quick Sequential Organ Failure Assessment (area under the curve, 0.82), Modified Shock Index (area under the curve, 0.79), and Shock Index (area under the curve, 0.77). Pairwise comparisons using DeLong\u2019s test showed that National Early Warning Score 2 performed significantly better than the other evaluated tools. In exploratory multivariable analysis, quick Sequential Organ Failure Assessment \u22652, Modified Shock Index \u22651.3, lactate &gt;2.0\u2009mmol\/L, and chronic kidney disease were independently associated with in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>National Early Warning Score 2 showed the best predictive performance for in-hospital mortality in adult emergency department patients with sepsis and may be a useful tool for early risk stratification in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261458634","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:13:46Z","timestamp":1781849626000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality prediction by quick Sequential Organ Failure Assessment, National Early Warning Score 2, Shock Index, and Modified Shock Index in suspected sepsis: A retrospective study"],"prefix":"10.1177","volume":"54","author":[{"given":"Xiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Rudong County People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Rudong Hospital of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"She","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rudong County People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7106-2215","authenticated-orcid":false,"given":"Hua","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rudong County People\u2019s Hospital, China"},{"name":"Department of Emergency Medicine, Affiliated Rudong Hospital of Xinglin College, Nantong University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3790-0"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-2310"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.6229"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e122"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.03.032"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0854OC"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101184"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.07.005"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2820"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-020-00764-3"},{"key":"e_1_3_6_13_2","first-page":"103462","article-title":". National early warning score (NEWS) 2 predicts hospital mortality from COVID-19 patients","volume":"76","author":"Wibisono E","year":"2022","unstructured":"Wibisono E, Hadi U, Bramantonoet\u00a0al . National early warning score (NEWS) 2 predicts hospital mortality from COVID-19 patients. Ann Med Surg (Lond) 2022; 76: 103462.","journal-title":"Ann Med Surg (Lond)"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-021-01620-x"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008014"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2021.12.023"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617741284"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030875"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-3-260"},{"key":"e_1_3_6_22_2","first-page":"10.7196\/AJTCCM.","article-title":"The usefulness of the shock index and the modified shock index in predicting patient outcomes in a tertiary emergency department in India","volume":"29","author":"Kalla IS","year":"2023","unstructured":"Kalla IS, Richards GA. The usefulness of the shock index and the modified shock index in predicting patient outcomes in a tertiary emergency department in India. Afr J Thorac Crit Care Med 2023; 29: 10.7196\/AJTCCM.2023.v29i2.1230.","journal-title":"Afr J Thorac Crit Care Med"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12060878"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ienj.2022.101242"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35144-6"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266755"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijciis.ijciis_41_22"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.04.006"},{"key":"e_1_3_6_30_2","first-page":"e10","article-title":"Assessment of the shock index in septic shock: A systematic review","volume":"48","author":"Diaztagle Fern\u00e1ndez JJ","year":"2024","unstructured":"Diaztagle Fern\u00e1ndez JJ, Casta\u00f1eda-Gonz\u00e1lez JP, Trujillo Zambrano JI, et\u00a0al. 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