{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:48:30Z","timestamp":1782449310724,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260312 and 82460307"],"award-info":[{"award-number":["82260312 and 82460307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program of Guizhou Medical University for Applying to the National Natural Science Foundation","award":["20NSP049"],"award-info":[{"award-number":["20NSP049"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between the percentage of peripheral natural killer cells and thyroid autoimmunity in women with a history of miscarriage and assess whether B-cells mediate this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study was conducted on 927 women with a history of miscarriage treated at the Affiliated Hospital of Guizhou Medical University (2021\u20132023). Peripheral T-cell, B-cell, and natural killer cell subsets and thyroid antibodies were assessed. Multivariable logistic regression, restricted cubic splines, and mediation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with thyroid autoimmunity had lower percentage of peripheral natural killer cells and higher percentage of B-cells than those without thyroid autoimmunity (both\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The percentage of peripheral natural killer cells demonstrated a consistent inverse association with thyroid autoimmunity after adjustment (adjusted odds ratios: 0.00; 95% confidence interval: 0.00\u20130.02; all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Restricted cubic spline analysis indicated a nonlinear dose\u2013response relationship that was stronger in women aged \u226535 years and in those without recurrent miscarriages. B-cells partially mediated the association between the percentage of peripheral natural killer cells and thyroid autoimmunity (31.4% of the total effect; ab\u2009=\u2009\u22120.166;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower percentage of peripheral natural killer cells is linked to higher odds of thyroid autoimmunity in women with a history of miscarriage, and B-cells partly explain this relationship, supporting the use of peripheral immune profiling to identify thyroid autoimmunity risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261458675","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:33:23Z","timestamp":1782207203000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inverse association between peripheral natural killer cells and thyroid autoimmunity in cases of miscarriage: Evidence from a cross-sectional study"],"prefix":"10.1177","volume":"54","author":[{"given":"Xin","family":"Guo","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Department of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, China"},{"name":"Reproductive Medicine Center, Guizhou Provincial People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Guizhou Medical University, Key Laboratory of Environmental Pollution and Disease Monitoring, Ministry of Education, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Gui\u2019an Branch of Guizhou Medical University Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Reproductive Immunization Center, Guangdong Provincial Reproductive Science Institute, NHC Key Laboratory of Male Reproduction and Genetics, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Department of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0431-1845","authenticated-orcid":false,"given":"Guanyou","family":"Huang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Department of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0457"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2616"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0190"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01869"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.622306"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-21-0024"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.018"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00406"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01906"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2017.09.008"},{"key":"e_1_3_9_12_2","first-page":"15","article-title":"The ratio of peripheral blood natural killer cells is not a solid surrogate immune index in unexplained recurrent miscarriage","volume":"21","author":"Yan N","year":"2024","unstructured":"Yan N, Lee P, Jie H, et\u00a0al. The ratio of peripheral blood natural killer cells is not a solid surrogate immune index in unexplained recurrent miscarriage. 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