{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:05:35Z","timestamp":1783919135729,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Henan Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["202300410458"],"award-info":[{"award-number":["202300410458"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between the high-sensitivity C-reactive protein-to-hemoglobin ratio and stroke risk among middle-aged and older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective follow-up study was conducted using cohort data from the China Health and Retirement Longitudinal Study (CHARLS) and the English Longitudinal Study of Ageing (ELSA). Participants without a history of stroke at baseline were included, comprising 5368 individuals from CHARLS and 1422 from ELSA. Cox proportional hazards regression models were used to analyze the association between C-reactive protein-to-hemoglobin ratio levels and stroke risk, along with dose\u2013response analyses and subgroup interaction testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjusting for sex, age, lifestyle factors, and multiple clinical biochemical indicators, the participants in Q2, Q3, and Q4 demonstrated a significantly higher risk of stroke than those in Q1 (reference group). The hazard ratios were 2.23 (1.35\u20133.69), 2.24 (1.36\u20133.71), and 3.14 (1.93\u20135.12), respectively (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Dose\u2013response analysis revealed an approximately linear positive association between C-reactive protein-to-hemoglobin ratio and stroke risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>C-reactive protein-to-hemoglobin ratio levels are significantly and positively associated with stroke risk in middle-aged and older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261459294","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:46:41Z","timestamp":1783655201000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of high-sensitivity C-reactive protein-to-hemoglobin ratio with stroke risk: A study based on the China Health and Retirement Longitudinal Study and English Longitudinal Study of Ageing cohorts"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8168-3466","authenticated-orcid":false,"given":"Mingyue","family":"Ding","sequence":"first","affiliation":[{"name":"Henan Provincial People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Qin","sequence":"additional","affiliation":[{"name":"Henan Provincial People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02686-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02314-y"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02122-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.12.015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02055-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1511319"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028058"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20200346"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02569-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000003909"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.131946"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02244-9"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae103"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-025-02928-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2024.10.017"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.047820"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-79520-x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-097075"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S432885"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad235"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107476"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261459294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261459294","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261459294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:46:20Z","timestamp":1783917980000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261459294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/03000605261459294"],"URL":"https:\/\/doi.org\/10.1177\/03000605261459294","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"03000605261459294"}}