{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:45:17Z","timestamp":1782632717186,"version":"3.54.5"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Joint Logistics Medical High-Quality Specialty of the Joint Logistics Support Force","award":["LQYZ-SZ"],"award-info":[{"award-number":["LQYZ-SZ"]}]},{"name":"900th Hospital of Joint Logistic Support Force Annual Hospital Research Plan","award":["2020Z09"],"award-info":[{"award-number":["2020Z09"]}]},{"name":"900th Hospital of Joint Logistic Support Force Annual Hospital Research Plan","award":["2021MS14"],"award-info":[{"award-number":["2021MS14"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Immunoglobulin A nephropathy is a common glomerular disease associated with mucosal immune dysregulation. We report the case of a young woman diagnosed with biopsy-proven immunoglobulin A nephropathy who achieved sustained clinical remission following sequential tonsillectomy and appendectomy performed for standard clinical indications. Tonsillectomy was associated with improvement in hematuria, whereas proteinuria persisted. Four years later, appendectomy for chronic appendicitis was followed by complete resolution of the proteinuria. The temporal association between these interventions and changes in disease activity is notable; however, causality cannot be established. This case highlights the potential relevance of extrarenal mucosal inflammatory conditions in selected patients with immunoglobulin A nephropathy and underscores the complexity of disease activity assessment. These observations should be considered hypothesis-generating and require further investigation.<\/jats:p>","DOI":"10.1177\/03000605261460293","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:40:13Z","timestamp":1782369613000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Remission of Immunoglobulin A nephropathy following sequential tonsillectomy and appendectomy: A case report"],"prefix":"10.1177","volume":"54","author":[{"given":"Peilan","family":"Zheng","sequence":"first","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force"},{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The 909th Hospital, School of Medicine, Xiamen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Weng","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force"},{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Xu","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force"},{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"},{"name":"900th Hospital of PLA Joint Logistic Support Force"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaohua","family":"Qiu","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force"},{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhong","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force"},{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinge","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"},{"name":"900th Hospital of Joint Logistics Support Force"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-1517","authenticated-orcid":false,"given":"Jiejian","family":"Chen","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force"},{"name":"Department of Nephrology, Fuzong Clinical Medical College of Fujian Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49778"},{"key":"e_1_3_3_3_2","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group","year":"2021","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int 2021; 100: S1\u2013S276.","journal-title":"Kidney Int"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.243"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00885-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.06.036"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.07.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14481"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-024-02530-6"},{"key":"e_1_3_3_11_2","article-title":"Effects of tonsillectomy and adenoidectomy on the immune system","volume":"10","author":"Liu Y","year":"2024","unstructured":"Liu Y, Liu T, Li X, et al. Effects of tonsillectomy and adenoidectomy on the immune system. 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