{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:14:18Z","timestamp":1783606458582,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperuricemia is a cardiometabolic risk factor among patients with hypertension. A high total cholesterol-to-high-density lipoprotein cholesterol ratio reflects atherogenic lipid imbalance and insulin resistance. This study investigated the association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension at Uganda Heart Institute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study among 277 consecutively recruited patients with hypertension aged \u226518 years from 4 August 2025 to 20 October 2025 at Uganda Heart Institute. Hyperuricemia was defined as a serum uric acid level of \u22657\u2005mg\/dL in men and \u22656\u2005mg\/dL in women, whereas a high total cholesterol-to-high-density lipoprotein cholesterol ratio was defined as \u22655.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 277 participants, 89 had hyperuricemia, giving a proportion of 32.1% (95% confidence interval: 26.9\u201337.9). Hyperuricemia was significantly more common in participants with a total cholesterol-to-high-density lipoprotein cholesterol ratio of\u2009\u22655 (53.8%) than in those with a ratio of &lt;5 (25.5%) (p\u2009&lt;\u20090.001). After adjustment for confounders, a high total cholesterol-to-high-density lipoprotein cholesterol ratio remained independently associated with hyperuricemia (adjusted odds ratio = 2.83, 95% confidence interval: 1.31\u20136.09, p\u2009=\u20090.008). The total cholesterol-to-high-density lipoprotein cholesterol ratio demonstrated moderate predictive ability for hyperuricemia, with an optimal cutoff value of 4.33 (sensitivity, 58%; specificity, 71%) and an area under the curve of 0.68 (95% confidence interval: 0.61\u20130.75).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hyperuricemia is prevalent among patients with hypertension. A high total cholesterol-to-high-density lipoprotein cholesterol ratio is a potential predictor of hyperuricemia in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261462032","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:06:16Z","timestamp":1783407976000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension: A cross-sectional study from central Uganda"],"prefix":"10.1177","volume":"54","author":[{"given":"Blendar","family":"Ainebyoona","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Mbarara University of Science and Technology"},{"name":"Department of Medical Laboratory, Entebbe Regional Referral Hospital, 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