{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:06:11Z","timestamp":1783933571493,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Effective pain management is critical following hemorrhoidectomy due to the dense nerve distribution in the anorectal region. Although compound methylene blue and liposomal bupivacaine are both used for postoperative analgesia, their comparative efficacy and safety profiles have not been systematically evaluated. This study aimed to compare the analgesic efficacy, opioid-sparing effects, and safety of liposomal bupivacaine with compound methylene blue in patients undergoing mixed hemorrhoidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center, prospective observational cohort study involving 150 patients undergoing elective hemorrhoidectomy for stage III\u2013IV mixed hemorrhoids. Patients were allocated into two groups: (a) the compound methylene blue group (n\u2009=\u200975) and (b) the liposomal bupivacaine group (n\u2009=\u200975). Postoperative pain was assessed using the numerical rating scale at rest over 72\u2005h. Primary outcomes included cumulative pain scores, time to first rescue analgesia, and total rescue opioid consumption. Secondary outcomes included patient satisfaction, recovery metrics, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The liposomal bupivacaine group demonstrated significantly lower cumulative pain scores over 72\u2005h than the compound methylene blue group. Although the compound methylene blue group demonstrated marginally better pain control in the immediate postoperative period, liposomal bupivacaine provided superior and stable analgesia from 12 to 72\u2005h. The proportion of patients who required rescue opioids was significantly lower in the liposomal bupivacaine group than in the compound methylene blue group. Patient satisfaction was significantly higher in the liposomal bupivacaine group. Furthermore, the incidence of adverse events was significantly lower in the liposomal bupivacaine group than in the compound methylene blue group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Single-dose perianal infiltration of liposomal bupivacaine provides superior and more sustained postoperative analgesia than that of compound methylene blue in patients who have undergone mixed hemorrhoidectomy. Liposomal bupivacaine significantly reduces rescue opioid requirements, delays the need for supplemental analgesia, and improves patient satisfaction with a favorable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261463066","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:11:21Z","timestamp":1783671081000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of compound methylene blue (methylene blue + ropivacaine) and bupivacaine liposome for pain control after mixed hemorrhoid surgery: A comprehensive analysis based on clinical studies"],"prefix":"10.1177","volume":"54","author":[{"given":"Guangzhi","family":"Mai","sequence":"first","affiliation":[{"name":"South China University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Yu","sequence":"additional","affiliation":[{"name":"South China University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6756-2362","authenticated-orcid":false,"given":"Jiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"South China University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000545793"},{"key":"e_1_3_2_3_2","article-title":"Risk factors for moderate to severe pain during the first 24 hours after laparoscopic bariatric surgery while receiving intravenous patient-controlled analgesia","author":"Iamaroon A","unstructured":"Iamaroon A, Tangwiwat S, Nivatpumin P, et al. Risk factors for moderate to severe pain during the first 24 hours after laparoscopic bariatric surgery while receiving intravenous patient-controlled analgesia. Anesthesiol Res Prac 2019; 2019:6593736.","journal-title":"Anesthesiol Res Prac"},{"key":"e_1_3_2_4_2","article-title":"Three acupuncture methods for postoperative pain in mixed hemorrhoids: a systematic review and network meta-analysis","author":"Ye S","unstructured":"Ye S, Zhou J, Guo X, et al. Three acupuncture methods for postoperative pain in mixed hemorrhoids: a systematic review and network meta-analysis. 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Infiltration of local anesthetic in the interspace between the popliteal artery and capsule of the posterior knee \u201cIPACK block\u201d versus adductor canal block \u201cACB\u201d for pain relief after open wedge high tibial osteotomy: a randomized clinical trial. Minerva Anestesiol 2024; 90: 618\u2013625.","journal-title":"Minerva Anestesiol"},{"key":"e_1_3_2_8_2","article-title":"Liposomal bupivacaine versus bupivacaine and dexamethasone intercostal nerve blocks for robotic thoracic surgery: a randomized clinical trial","author":"Ganguly K","unstructured":"Ganguly K, Van Helmond N, Friedman A, et al. Liposomal bupivacaine versus bupivacaine and dexamethasone intercostal nerve blocks for robotic thoracic surgery: a randomized clinical trial. 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