{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:15:17Z","timestamp":1783149317358,"version":"3.54.6"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100016114","name":"Zhejiang Medical Association","doi-asserted-by":"publisher","award":["No. 2025ZYC-A355"],"award-info":[{"award-number":["No. 2025ZYC-A355"]}],"id":[{"id":"10.13039\/501100016114","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission","award":["No. 2024KY1824, No. 2025KY1871,"],"award-info":[{"award-number":["No. 2024KY1824, No. 2025KY1871,"]}]},{"name":"The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission","award":["No. 2025HY1473"],"award-info":[{"award-number":["No. 2025HY1473"]}]},{"name":"Zhejiang Provincial Program for Science and Technology Development in Traditional Chinese Medicine","award":["No. 2026ZL0149"],"award-info":[{"award-number":["No. 2026ZL0149"]}]},{"name":"The Science and Technology Project of Taizhou","award":["No. 23ywb70, No.24ywa44"],"award-info":[{"award-number":["No. 23ywb70, No.24ywa44"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the clinical outcomes and prognosis of regional citrate anticoagulation and systemic heparin anticoagulation in patients with sepsis-associated acute kidney injury undergoing continuous renal replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study (2020\u20132024) included 168 adults with sepsis-associated acute kidney injury who received continuous renal replacement therapy at the intensive care unit of Taizhou Municipal Hospital. Kaplan\u2013Meier curves and multivariable Cox regression were used to evaluate 14- and 28-day mortality, with subgroup analyses performed to assess effect modification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 168 eligible patients, 1:1 propensity score matching yielded 42 well-balanced pairs (regional citrate anticoagulation, n\u2009=\u200942; systemic heparin anticoagulation, n\u2009=\u200942) with comparable baseline characteristics. Hospital mortality was lower with regional citrate anticoagulation (59.5%) than with systemic heparin anticoagulation (71.4%); however, the difference did not reach statistical significance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.251). The 14-day comparison demonstrated a higher survival probability with regional citrate anticoagulation (log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.043; hazard ratio, 2.10; 95% confidence interval: 1.01\u20134.39), and a similar benefit persisted at 28 days (log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.042; hazard ratio, 1.76; 95% confidence interval: 1.01\u20133.05). Subgroup analysis further indicated that the survival benefit of regional citrate anticoagulation on 28-day mortality was most pronounced among patients with pre-existing hypertension (hazard ratio, 2.75; 95% confidence interval: 1.32\u20135.71;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.007; interaction\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with sepsis-associated acute kidney injury requiring continuous renal replacement therapy, regional citrate anticoagulation may confer better short-term (14- and 28-day) survival than systemic heparin anticoagulation; however, no clear difference in overall hospital mortality was observed. This potential benefit may be more pronounced among patients with hypertension, meriting further evaluation of tailored anticoagulation approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261464273","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:39:37Z","timestamp":1782916777000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional citrate versus systemic heparin anticoagulation in continuous renal replacement therapy for sepsis-associated acute kidney injury: A retrospective cohort study of short-term outcomes"],"prefix":"10.1177","volume":"54","author":[{"given":"Jian","family":"Lan","sequence":"first","affiliation":[{"name":"Taizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Mao","sequence":"additional","affiliation":[{"name":"Taizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Shi","sequence":"additional","affiliation":[{"name":"Taizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-857X","authenticated-orcid":false,"given":"Qingqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University"},{"name":"Neurorehabilitation Center, Taizhou Rehabilitation Hospital, Taizhou Enze Medical Center (Group), China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangwen","family":"Cai","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang University School of Medicine"},{"name":"Institute of Gastroenterology, Zhejiang University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-7800","authenticated-orcid":false,"given":"Xijiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Taizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9472-1807","authenticated-orcid":false,"given":"Cheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Taizhou University"},{"name":"Taizhou Key Laboratory of Sepsis, Taizhou Municipal Hospital, China"},{"name":"Taizhou Key Laboratory of Infection and Tumor Immunology, Taizhou Municipal Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20198595"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.278"},{"key":"e_1_3_3_4_2","article-title":"Sepsis associated acute kidney injury","volume":"364","author":"Poston JT","year":"2019","unstructured":"Poston JT, Koyner JL. 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