{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:05:21Z","timestamp":1784264721191,"version":"3.55.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["K112204322"],"award-info":[{"award-number":["K112204322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To develop S1-4 aptamer-conjugated citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles and evaluate their targeting ability and magnetic hyperthermia effect against MCF-7 breast cancer cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles were synthesized by chemical co-precipitation and subsequently conjugated with the S1-4 aptamer to fabricate S1-4 aptamer-conjugated citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles. The nanoparticles were characterized by X-ray diffraction, transmission electron microscopy, dynamic light scattering, zeta potential analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. Biocompatibility was assessed in MCF-7 and MEF cells; cellular targeting was examined by Prussian blue staining; and the magnetic hyperthermia effect under an alternating magnetic field was evaluated by cell viability, live\/dead staining, and apoptosis assays.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Compared with citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles, S1-4 aptamer-conjugated citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles exhibited a larger hydrodynamic diameter (17\u2009\u00b1\u20094\u2005nm vs. 8\u2009\u00b1\u20093\u2005nm) and a more negative surface charge (\u221226.7\u2009\u00b1\u20090.3\u2005mV vs. \u221219.7\u2009\u00b1\u20090.5\u2005mV). Fourier transform infrared spectroscopy confirmed successful aptamer conjugation. Both nanoparticles demonstrated good biocompatibility in MCF-7 and MEF cells. Prussian blue staining demonstrated stronger cellular uptake of S1-4 aptamer-conjugated citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles in MCF-7 cells. Under alternating magnetic field exposure, S1-4 aptamer-conjugated citric acid-coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles produced a significantly greater hyperthermia effect than the controls, resulting in reduced cell proliferation and increased apoptosis in MCF-7 cells (P\u2009&lt;\u20090.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    S1-4 aptamer-mediated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles demonstrated active targeting ability and enhanced the antitumor effect of alternating magnetic field\u2013mediated magnetic hyperthermia in breast cancer cells and maintained low cytotoxicity under the tested conditions, suggesting that they may be a feasible platform for targeted magnetic hyperthermia.\n                  <\/jats:p>","DOI":"10.1177\/03000605261464285","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:52:32Z","timestamp":1784040752000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["S1-4 aptamer-mediated iron oxide nanoparticles for targeted magnetic hyperthermia in MCF-7 breast cancer cells"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2472-9371","authenticated-orcid":false,"given":"Enyuan","family":"Chen","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yin","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Miao","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifang","family":"Ni","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-024-1058-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.012"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103160"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03111-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.113754"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29061352"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167653"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100220"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071397"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S453601"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB00167A"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S477652"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.109.034603"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15317"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S281029"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano12030343"},{"key":"e_1_3_3_19_2","first-page":"1003","article-title":"Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity","volume":"8","author":"Alvarez-Berr\u00edos MP","year":"2013","unstructured":"Alvarez-Berr\u00edos MP, Castillo A, Mend\u00e9z J, et al. 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