{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T07:14:50Z","timestamp":1783235690358,"version":"3.54.6"},"reference-count":43,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary aldosteronism is a common and underdiagnosed form of secondary hypertension. However, preclinical investigations of adrenal ablation as a potential therapeutic approach for primary aldosteronism treatment are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A deoxycorticosterone acetate\u2013salt hypertensive rat model was established, and the animals were treated with either unilateral adrenal ablation or oral spironolactone for 12 weeks. Blood pressure was continuously monitored throughout the study period. The key endpoints included blood pressure regulation, circulating hormone levels, and target organ damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adrenal ablation markedly reduced blood pressure in deoxycorticosterone acetate\u2013salt hypertensive rats. During the first 8 weeks of treatment, the antihypertensive effect exerted by adrenal ablation was significantly greater than that achieved using oral spironolactone. After 8 weeks, the blood pressure\u2013lowering effects of both interventions were comparable, although each effect remained significantly lower than that in the untreated controls. Moreover, adrenal ablation was more effective than spironolactone in attenuating the target organ damage associated with deoxycorticosterone acetate\u2013salt hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with oral spironolactone, adrenal ablation significantly lowered blood pressure and more effectively attenuated target organ damage in deoxycorticosterone acetate\u2013salt hypertensive rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261464286","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:21:52Z","timestamp":1782966112000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of adrenal ablation on blood pressure and target organ damage in deoxycorticosterone acetate\u2013salt hypertensive 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