{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:07:00Z","timestamp":1784185620378,"version":"3.55.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["No. 2026-3-042"],"award-info":[{"award-number":["No. 2026-3-042"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Pulmonary embolism is a common and potentially life-threatening acute condition encountered in clinical practice. Neuroendocrine tumors are heterogeneous neoplasms characterized by diverse biological behaviors, and patients with poorly differentiated or advanced neuroendocrine tumors may have an increased risk of developing venous thromboembolism. We report the case of a 60-year-old female who experienced acute chest discomfort and was diagnosed with pulmonary embolism. Comprehensive evaluation revealed no evidence of lower limb thrombosis, autoimmune or hematologic disorders, or other identifiable causes. The emboli resolved following anticoagulant therapy. Seventeen months later, the patient developed upper abdominal pain and underwent a colonoscopy, which revealed a lesion approximately 20\u2005cm proximal to the terminal ileum. Histopathological and immunohistochemical analyses confirmed a grade-1 neuroendocrine tumor.\n                    <jats:sup>18<\/jats:sup>\n                    F-octreotide positron emission tomography\u2013computed tomography demonstrated increased tracer uptake in the terminal ileum and multiple hepatic foci, consistent with an ileal neuroendocrine tumor with liver metastases. The patient received intramuscular octreotide acetate microspheres (20\u2005mg every 4 weeks) and remained clinically stable during follow-up. This case underscores the importance of considering occult malignancy in older patients presenting with unprovoked pulmonary embolism. Small intestinal neuroendocrine tumors may remain clinically silent for extended periods and should be included in the differential diagnosis when common etiologies have been excluded.\n                  <\/jats:p>","DOI":"10.1177\/03000605261465290","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:24:51Z","timestamp":1783927491000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["From pulmonary embolism to small intestinal neuroendocrine tumor: A new diagnostic perspective"],"prefix":"10.1177","volume":"54","author":[{"given":"Zhenping","family":"Wu","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angcheng","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Jinhua Hospital, Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoqun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"He","sequence":"additional","affiliation":[{"name":"Anting Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7297-7448","authenticated-orcid":false,"given":"Ting","family":"Jin","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"588\u2013593","article-title":"Thrombotic risk in gastroenteropancreatic neuroendocrine tumor patients: a single-center experience","volume":"34","author":"Massironi S","year":"2021","unstructured":"Massironi S, Cavalcoli F, Artoni A, et al. Thrombotic risk in gastroenteropancreatic neuroendocrine tumor patients: a single-center experience. Ann Gastroenterol 2021; 34: 588\u2013593.","journal-title":"Ann Gastroenterol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17020212"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.008"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13423"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4341"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195542"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167203"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31079"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40507.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000497355"},{"key":"e_1_3_2_12_2","first-page":"95","volume-title":"Platelets and angiogenesis in malignancySeminars in thrombosis and hemostasis","author":"Sierko E","unstructured":"Sierko E, Wojtukiewicz MZ. Platelets and angiogenesis in malignancy. In: Seminars in thrombosis and hemostasis, 1 February 2004, pp.95\u2013108."},{"key":"e_1_3_2_13_2","first-page":"46","article-title":"Epidemiology of cancers of the small intestine: trends, risk factors, and prevention","volume":"7","author":"Barsouk A","year":"2019","unstructured":"Barsouk A, Rawla P, Barsouk A, et al. Epidemiology of cancers of the small intestine: trends, risk factors, and prevention. 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