{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:13:54Z","timestamp":1783692834400,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hangzhou city Medical and science project","award":["B20260055; B20262199; B20262289"],"award-info":[{"award-number":["B20260055; B20262199; B20262289"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the value of neutrophil extracellular traps biomarkers (myeloperoxidase and citrullinated histone H3) in patients with bronchial asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 66 patients with bronchial asthma (stratified into mild, moderate, and severe lung function obstruction subgroups according to predicted forced expiratory volume in 1 second) and 60 healthy controls were enrolled. Plasma levels of myeloperoxidase and citrullinated histone H3 were measured. Spearman correlation analysis and receiver operating characteristic curve analysis were used to evaluate correlations and diagnostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with healthy controls, patients with bronchial asthma had significantly higher plasma levels of myeloperoxidase and citrullinated histone H3 (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Myeloperoxidase and citrullinated histone H3 levels increased with the severity of lung function obstruction (severe &gt; moderate &gt; mild; all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Receiver operating characteristic analysis showed that the area under the curve for myeloperoxidase and citrullinated histone H3 alone in diagnosing bronchial asthma was 0.824 and 0.867, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma myeloperoxidase and citrullinated histone H3 are elevated in patients with bronchila asthma and are closely associated with the severity of lung function obstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261466531","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:34:15Z","timestamp":1783521255000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil extracellular traps biomarkers are associated with lung function obstruction severity in bronchial asthma"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5156-1195","authenticated-orcid":false,"given":"Yueyan","family":"Mao","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine Second Affiliated Hospital Linping Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Fan","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine Second Affiliated Hospital Linping Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Linping District"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4253"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15197"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.10.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201719"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2018.1519804"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108150"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0241-2021"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14059"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00750-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1493684"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2013.121246"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1651085"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000048645"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-025-07334-9"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261466531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261466531","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261466531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:19:50Z","timestamp":1783689590000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261466531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/03000605261466531"],"URL":"https:\/\/doi.org\/10.1177\/03000605261466531","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"03000605261466531"}}