{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:44:54Z","timestamp":1785703494731,"version":"3.56.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Scientific Research Start-up Fund of the Affiliated Hospital of Southwest Medical University"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hypertension is a common and modifiable cardiovascular risk factor. The triglyceride\u2013total cholesterol\u2013body weight index is a novel metabolic indicator derived from routine clinical measurements, but its association with hypertension remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This longitudinal cohort study used data from 5,731 middle-aged and older adults from the English Longitudinal Study of Ageing, with cross-sectional, prospective, and trajectory analyses. Hypertension was defined as a mean systolic blood pressure \u2265140 mmHg, a mean diastolic blood pressure \u226590 mmHg, antihypertensive medication use, or self-reported physician-diagnosed hypertension. For the prospective analysis, participants without hypertension at baseline were followed for a median of 12 years. For the trajectory analysis, repeated triglyceride\u2013total cholesterol\u2013body weight index measurements from previous waves were used to identify long-term triglyceride\u2013total cholesterol\u2013body weight index patterns and assess their associations with hypertension risk. Subgroup analyses and propensity score matching were performed to assess the robustness of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the cross-sectional analyses, each one-unit increase in log-transformed triglyceride\u2013total cholesterol\u2013body weight index was associated with 43% higher odds of hypertension (adjusted odds ratio = 1.43, 95% confidence interval: 1.31\u20131.55). In the prospective analyses, baseline triglyceride\u2013total cholesterol\u2013body weight index predicted incident hypertension (adjusted hazard ratio\u2009=\u20091.16, 95% confidence interval: 1.05\u20131.28). Trajectory analyses identified low, moderate, and high triglyceride\u2013total cholesterol\u2013body weight index patterns, showing a graded increase in hypertension risk. Compared with the low-trajectory group, the high-triglyceride\u2013total cholesterol\u2013body weight index group had 69% higher odds of hypertension (adjusted odds ratio = 1.69, 95% confidence interval: 1.37\u20132.09, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Triglyceride\u2013total cholesterol\u2013body weight index was independently and positively associated with the risk of hypertension and may provide a simple measure of metabolic burden relevant to early risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261470980","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:29:07Z","timestamp":1785425347000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel nutritional index for hypertension risk and prediction: Cross-sectional, prospective, and trajectory evidence from the English Longitudinal Study of Ageing"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-0837","authenticated-orcid":false,"given":"Fulong","family":"Luo","sequence":"first","affiliation":[{"name":"Xuanwu Hospital, Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1950-5682","authenticated-orcid":false,"given":"Yue","family":"Cao","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital, Southwest Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018912"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.13896"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02173-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2506201"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-025-04500-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1616520"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-025-07203-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S467577"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113311"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"issue":"124","key":"e_1_3_2_13_2","article-title":"Association of atherogenic index of plasma trajectory with the incidence of cardiovascular disease over a 12-year follow-up: findings from the ELSA cohort study","volume":"24","author":"Xicong L","year":"2025","unstructured":"Xicong L, Lifei L, Yubiao C, et al. 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