{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:02:48Z","timestamp":1785394968368,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus is associated with increased cardiovascular morbidity, even in the absence of overt clinical disease. Sestrin-1 is a stress-responsive antioxidant protein implicated in oxidative homeostasis and cardiovascular protection. This study aimed to evaluate serum Sestrin-1 levels in patients with systemic lupus erythematosus and examine their relationship with subclinical cardiovascular findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this controlled cross-sectional study, 60 patients with systemic lupus erythematosus and 60 age-matched healthy controls underwent clinical assessment, laboratory testing, 12-lead electrocardiography, transthoracic echocardiography, and carotid intima-media thickness measurement. Serum Sestrin-1 was measured by enzyme-linked immunosorbent assay (ELISA). Between-group comparisons used parametric or nonparametric tests according to data distribution. Within the systemic lupus erythematosus cohort, correlations between Sestrin-1 and disease activity (Systemic Lupus Erythematosus Disease Activity Index), as well as cardiovascular parameters, were assessed. An exploratory multivariable logistic regression model including Sestrin-1, left atrial diameter, corrected QT interval, age, and sex was constructed to identify variables associated with case status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum Sestrin-1 levels were significantly lower in patients with systemic lupus erythematosus than in controls (9.99\u2009\u00b1\u20092.01 vs. 17.79\u2009\u00b1\u20095.11\u2005ng\/mL; p\u2009&lt;\u20090.001). Patients with systemic lupus erythematosus had a significantly longer corrected QT interval (429.65\u2009\u00b1\u200932.42 vs. 376.26\u2009\u00b1\u200933.41\u2005ms; p\u2009&lt;\u20090.001). In the exploratory multivariable logistic regression analysis, lower Sestrin-1 (per 1ng\/mL increase, odds ratio 0.63; 95% confidence interval: 0.54\u20130.75; p\u2009&lt;\u20090.001), larger left atrial diameter (per 1\u2005mm increase, odds ratio 1.13; 95% confidence interval: 1.06\u20131.22; p\u2009&lt;\u20090.001)), and longer corrected QT interval (per 1ms increase, odds ratio 1.03; 95% confidence interval: 1.02\u20131.05; p\u2009&lt;\u20090.001) were independently associated with systemic lupus erythematosus status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with systemic lupus erythematosus exhibit markedly reduced serum Sestrin-1 levels together with subclinical cardiovascular abnormalities. The inverse relationship between Sestrin-1 and left atrial diameter suggests a possible link between reduced antioxidant defense and early atrial remodeling in systemic lupus erythematosus. Sestrin-1 may represent a promising candidate biomarker for subclinical cardiovascular involvement in patients with systemic lupus erythematosus; however, prospective studies are needed to confirm its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261470988","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:57:21Z","timestamp":1785160641000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced serum Sestrin-1 is associated with subclinical cardiovascular alterations in systemic lupus erythematosus: A controlled cross-sectional study"],"prefix":"10.1177","volume":"54","author":[{"given":"Cahit","family":"Ucar","sequence":"first","affiliation":[{"name":"Necmettin Erbakan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Celik","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mevlut Hakan","family":"Goktepe","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-6184","authenticated-orcid":false,"given":"Mustafa Turgut","family":"Yildizgoren","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Ilanbey","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biochemistry, K\u0131r\u015fehir Ahi Evran University K\u0131r\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Kucuk","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"02","article-title":"Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics","volume":"10","author":"Dai X","year":"2025","unstructured":"Dai X, Fan Y, Zhao X. Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics. Signal Transduct Target Ther 2025; 10: 102.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2024-001152"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.15.33"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07574-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-031620-092317"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.11.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.5152\/ArchRheumatol.2025.11138"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S523175"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13705"},{"key":"e_1_3_2_13_2","first-page":"255","article-title":"Decreased plasma levels of Sestrin-1 and Sestrin-2 in patients with coronary artery disease and their association with the disease severity","volume":"16","author":"Heidar Beygi S","year":"2025","unstructured":"Heidar Beygi S, Namazi G, Asa P, et al. Decreased plasma levels of Sestrin-1 and Sestrin-2 in patients with coronary artery disease and their association with the disease severity. Caspian J Intern Med 2025; 16: 255\u2013262.","journal-title":"Caspian J Intern Med"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12051126"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12820"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.21470\/1678-9741-2024-0038"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13052"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261470988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261470988","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261470988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:48:07Z","timestamp":1785394087000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261470988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/03000605261470988"],"URL":"https:\/\/doi.org\/10.1177\/03000605261470988","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"03000605261470988"}}