{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:44:51Z","timestamp":1787330691811,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The increasing prevalence of osteoporosis has exerted a substantial global economic burden. Low hemoglobin levels and low bone density frequently co-occur in older adults. This study aimed to elucidate the relationship between whole blood cell count and bone density among individuals aged \u226550 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study was conducted from January 2024 to March 2024, which enrolled 83 participants aged \u226550 years. Demographic and clinical characteristics were recorded. Comprehensive complete blood cell count tests were performed, and lumbar bone mineral density (L1\u2013L4) was measured using dual-energy X-ray absorptiometry. Linear regression and restricted cubic spline analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Red blood cell count and hemoglobin levels were positively correlated with lumbar bone mineral density. This association remained significant in males but was not observed in females. Nonlinear relationships were observed between hemoglobin levels, platelet levels, and lumbar bone mineral density, with platelet levels exhibiting an inverted U-shaped curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this retrospective cross-sectional study involving older Chinese individuals, hemoglobin levels demonstrated a positive, nonlinear association with lumbar bone mineral density, particularly among males. Although monitoring of hemoglobin levels may serve as a useful adjunct for early risk assessment of lumbar bone metabolic disorders, these findings are preliminary and causal inferences cannot be drawn due to the cross-sectional design. Further large-scale longitudinal studies are warranted to validate these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261474625","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:52:51Z","timestamp":1787143971000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective cross-sectional associations of whole blood cell count and hemoglobin level with lumbar bone mineral density in older adults"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2347-0549","authenticated-orcid":false,"given":"Fengxian","family":"Cao","sequence":"first","affiliation":[{"name":"Jinxi People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfu","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinxi People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Jinxi People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Outpatient Department, Dianshanhu People's Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Jinxi People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzheng","family":"He","sequence":"additional","affiliation":[{"name":"Jinxi People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Practice, Jinxi Community Health Center, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"105","article-title":"The epidemiology of osteoporosis","volume":"133","author":"Clynes MA","year":"2020","unstructured":"Clynes MA, Harvey NC, Curtis EM, et al. 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