{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:14:17Z","timestamp":1788081257690,"version":"build-2784847793"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shanghai Municipal civil Affairs Bureau","award":["Grant No. MZKT-2026-01-39"],"award-info":[{"award-number":["Grant No. MZKT-2026-01-39"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Omeprazole is commonly prescribed to psychiatric inpatients with polypharmacy; however, empiric initiation, prolonged treatment, intravenous use, and screening-flagged potential drug\u2013drug interactions or co-administration patterns may complicate medication review. This study described omeprazole prescribing patterns, appropriateness, and utilization intensity in a psychiatric specialty hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study used routinely collected data from hospital information systems and electronic health records of a municipal psychiatric specialty hospital in Shanghai, China. Consecutive inpatient omeprazole orders issued between 1 February 2023 and 31 December 2024 were screened. After excluding invalid, duplicate, and incomplete records, 152 eligible prescriptions of 71 inpatients were analyzed. Outcomes included guideline concordance for indication, dose, duration or review plan, route of administration, drug\u2013drug interaction\u2013based utilization, IV use, and screening-flagged potential drug\u2013drug interactions or co-administration patterns. Analyses were primarily descriptive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Appropriate indication was documented in 57\/152 prescriptions (37.5%), dose appropriateness in 147\/152 (96.7%), and guideline-concordant duration or review plan in 36\/152 (23.7%). Overall, 31\/152 prescriptions (20.4%) were fully appropriate, 22\/152 (14.5%) needed to be optimized, and 99\/152 (65.1%) were inappropriate; thus, 121\/152 prescriptions (79.6%) were not fully appropriate. Screening-flagged potential drug\u2013drug interactions or co-administration patterns were present in 77\/152 prescriptions (50.7%). Weighted exposure was 1.86 drug\u2013drug interactions per treatment day. Intravenous therapy accounted for 13.1% of treatment days and 21.6% of total drug\u2013drug interactions, with a median intravenous course duration of 7 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Omeprazole prescribing frequently showed non-concordance with predefined appropriateness criteria, mainly involving indication documentation or selection, treatment duration, and route optimization. Screening-flagged potential drug\u2013drug interactions and drug\u2013drug interaction\/day should be interpreted as medication-review and utilization signals rather than as confirmed adverse events or direct evidence of inappropriate prescribing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261474673","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:29:22Z","timestamp":1787902162000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Medication-safety burden of omeprazole in psychiatric inpatients: A retrospective cross-sectional study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6351-3532","authenticated-orcid":false,"given":"Wenjing","family":"Hu","sequence":"first","affiliation":[{"name":"Shanghai First Mental Health Center, Municipal Civil Affairs Bureau"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPO.2024.0059"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61091569"},{"key":"e_1_3_3_4_2","volume-title":"Notice on issuing the guiding principles for the clinical application of proton pump inhibitors (2020 Edition)","author":"General Office of the National Health Commission of the People\u2019s Republic of China","year":"2020","unstructured":"General Office of the National Health Commission of the People\u2019s Republic of China. 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