{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:44:47Z","timestamp":1787330687992,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Special Fund of the National Clinical Key Specialty Construction Program, P. R. China"},{"name":"the Key Project of the Tibet Autonomous Region Natural Science Foundation","award":["XZ202401ZR0063"],"award-info":[{"award-number":["XZ202401ZR0063"]}]},{"name":"JST SPRING","award":["JPMJSP2110"],"award-info":[{"award-number":["JPMJSP2110"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the associations of the triglyceride\u2013cholesterol\u2013body weight index with microvascular complications and assess its incremental value beyond conventional variables and its components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included Tibetan adults with type 2 diabetes from the China National Diabetic Chronic Complications Study. Logistic regression and restricted cubic spline analyses were used to evaluate the associations of triglyceride\u2013cholesterol\u2013body weight index with albuminuria, reduced estimated glomerular filtration rate, and diabetic retinopathy. Triglyceride\u2013cholesterol\u2013body weight index was compared with triglycerides, total cholesterol, body weight, body mass index, and the Castelli risk indices. The incremental predictive value of albuminuria was assessed using the 10-fold cross-validated area under the receiver operating characteristic curve, Brier score, and calibration slope. A sensitivity analysis excluded patients receiving lipid-lowering medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 662 participants, 657 contributed to the renal analyses and 575 to the retinopathy analyses. The prevalence of albuminuria increased from 40.0% in the lowest quartile to 54.9% in the highest quartile. After full adjustment, triglyceride\u2013cholesterol\u2013body weight index was not associated with albuminuria (odds ratio per 1-standard deviation increase, 1.09; 95% confidence interval: 0.91\u20131.32; p\u2009=\u20090.355), reduced estimated glomerular filtration rate, or diabetic retinopathy. Spline analyses showed no evidence of nonlinearity. Adding triglyceride\u2013cholesterol\u2013body weight index changed the cross-validated area under the receiver operating characteristic curve from 0.728 to 0.725 and did not improve the Brier score or calibration slope. Triglyceride\u2013cholesterol\u2013body weight index provided no improvement beyond its components. Excluding patients receiving lipid-lowering medications yielded a similar estimate for albuminuria (odds ratio = 1.10; 95% confidence interval: 0.91\u20131.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Triglyceride\u2013cholesterol\u2013body weight index reflected a metabolic profile but was not independently associated with microvascular outcomes. No incremental value beyond conventional clinical variables and its components was demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261475109","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:53:05Z","timestamp":1787143985000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Triglyceride\u2013cholesterol\u2013body weight index and microvascular complications in Tibetan adults with type 2 diabetes: A cross-sectional study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-9380","authenticated-orcid":false,"given":"Zhining","family":"Zhang","sequence":"first","affiliation":[{"name":"Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Tian","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-6182","authenticated-orcid":false,"given":"Lihui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Science and Education, People's Hospital of Xizang Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00299-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22208"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0027"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.04.027"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39864-w"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605261437612"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.02.039"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1352030"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1698297"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2025.104532"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.4.730"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10924"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","unstructured":"KDIGO 2024 Clinical practice guideline for the evaluation and management of chronic kidney disease. 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