{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:17:34Z","timestamp":1787753854417,"version":"build-2784847793"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Military Research Project for Military Applications","award":["2023YXKY034"],"award-info":[{"award-number":["2023YXKY034"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Drug-induced myocarditis is a rare but serious adverse events that may have a significant impact on patient prognosis. To identify signals of disproportionate reporting associated with drug-induced myocarditis, we conducted descriptive and disproportionality analyses of the United States Food and Drug Administration Adverse Event Reporting System database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed Food and Drug Administration Adverse Event Reporting System data from 2004 to 2023, focusing on myocarditis-related reports. We examined patient demographics, clinical prognosis, reporting country, and reporter type. A disproportionality analysis was conducted to assess the association between drugs and myocarditis, focusing on the 50 most frequently reported drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 20,753,288 adverse events in the Food and Drug Administration Adverse Event Reporting System database, 9014 (0.04%) were cases of drug-induced myocarditis, with reports increasing from 101 in 2004 to 1543 in 2023. Most cases occurred in male patients (52.63%) and patients aged 41\u201364 years, with chemotherapeutic agents being the drug group most commonly associated with myocarditis, making cancer the leading indication (32.5%). The United States reported the highest number of cases (20.87%). Physicians and pharmacists submitted the majority of reports (42.62% and 25.96%, respectively). Clinical outcomes included hospitalization (35.24%) and death (12.82%). Clozapine was the most frequently reported drug, whereas phendimetrazine showed the strongest association with myocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identifies key risk factors for drug-induced myocarditis using Food and Drug Administration Adverse Event Reporting System data. Although cases are rare, their severity highlights the need for improved monitoring. Enhanced pharmacovigilance, especially for high-risk drugs, is crucial to reduce the incidence of myocarditis and improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261475733","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:29:02Z","timestamp":1787585342000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Disproportionality analysis of drug-induced myocarditis: Insights from the Food and Drug Administration Adverse Event Reporting System database"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7138-1626","authenticated-orcid":false,"given":"Jingling","family":"Pang","sequence":"first","affiliation":[{"name":"The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyun","family":"Guo","sequence":"additional","affiliation":[{"name":"The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.05.013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2023.10.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.922782"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz026"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145186"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871523011312010003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.102"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.037"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30533-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2012.07.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30457-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.677"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2014"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-0735-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.616505"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109365"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0447-OA"},{"key":"e_1_3_3_19_2","article-title":"Cardiotoxicity of Immune Checkpoint Inhibitors","volume":"23","author":"Patel RP","unstructured":"Patel RP, Parikh R, Gunturu KS, et al. 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