{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:31:49Z","timestamp":1787232709435,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZZYSM202108013"],"award-info":[{"award-number":["SZZYSM202108013"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374605"],"award-info":[{"award-number":["82374605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate short-term diffusion tensor imaging-derived changes in the knee physis after whole-body vibration and to assess postural stability in healthy adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single-arm, within-subject exploratory study included 48 healthy adolescents (24 males and 24 females; mean age, 11.94 \u00b1 2.31 years) who underwent a 1-week whole-body vibration protocol (15 Hz, 5 mm amplitude). Fractional anisotropy and apparent diffusion coefficient values of the distal femoral and proximal tibial physes were measured before and after whole-body vibration using knee diffusion tensor imaging. Postural stability was evaluated using force plate center-of-pressure parameters. Paired comparisons were performed for the overall cohort and sex-stratified subgroups, and age- and bone age\u2013related trends were explored using quadratic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the overall cohort, fractional anisotropy increased in both the distal femoral physis (0.472 \u00b1 0.074 to 0.515 \u00b1 0.070; mean change, 0.043; Cohen's dz = 0.737; p &lt; 0.001) and the proximal tibial physis (0.486 \u00b1 0.063 to 0.527 \u00b1 0.067; mean change, 0.041; Cohen's dz = 0.897; p &lt; 0.001). Apparent diffusion coefficient decreased in the distal femoral physis (1.171 \u00b1 0.230 to 1.081 \u00b1 0.160 \u00d7 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s; mean change, \u22120.090; Cohen's dz = \u22120.483; p = 0.002) and the proximal tibial physis (1.171 \u00b1 0.211 to 1.100 \u00b1 0.168 \u00d7 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s; mean change, \u22120.071; Cohen's dz = \u22120.584; p &lt; 0.001). Sex-stratified analyses showed generally larger standardized changes in males, whereas apparent diffusion coefficient changes in females did not reach statistical significance. Exploratory scatter plots and quadratic regression models suggested that the magnitude of diffusion tensor imaging-derived changes varied with chronological age and bone age, with a trend toward larger changes within a bone age range of 12\u201314 years. Postural stability parameters increased transiently but remained within the \u201cno-impact\u201d safety threshold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 1-week whole-body vibration protocol was associated with measurable diffusion tensor imaging-derived changes in the adolescent knee physis and transient changes in postural stability. These findings should be interpreted as preliminary, hypothesis-generating biophysical observations rather than direct evidence of improved physeal function, growth promotion, or beneficial structural effects. Larger sham-controlled longitudinal studies incorporating growth outcomes and complementary diffusion tensor imaging metrics are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261476584","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:12:40Z","timestamp":1787076760000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-term whole-body vibration in adolescents: A prospective single-arm study of diffusion tensor imaging-derived changes in the knee physis and postural stability"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-5762","authenticated-orcid":false,"given":"Han","family":"Yang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine"},{"name":"Department of Tuina, Guangdong Provincial Hospital of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5403-118X","authenticated-orcid":false,"given":"Si-yuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-qing","family":"Liao","sequence":"additional","affiliation":[{"name":"Gannan Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-yu","family":"Hu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yuan","family":"Tong","sequence":"additional","affiliation":[{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-ling","family":"Yu","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-you","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University Huzhou Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-song","family":"Han","sequence":"additional","affiliation":[{"name":"Daqing People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-lin","family":"Xu","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Heilongjiang University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Lu","sequence":"additional","affiliation":[{"name":"Shenzhen Pingle Orthopedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0187-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8184"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.580314"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.976565"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-023-05753-z"},{"key":"e_1_3_3_7_2","article-title":"Can diffusion tensor imaging unlock the secrets of the growth plate?","volume":"6","author":"Kvist O.","unstructured":"Kvist O., Santos L. A., De Luca F, et al. Can diffusion tensor imaging unlock the secrets of the growth plate? BJR Open 2024; 6: tzae005.","journal-title":"BJR Open"},{"key":"e_1_3_3_8_2","first-page":"254","article-title":"The physical and biological basis of quantitative parameters derived from diffusion MRI","volume":"2","author":"Winston GP","year":"2012","unstructured":"Winston GP. The physical and biological basis of quantitative parameters derived from diffusion MRI. Quant Imaging Med Surg 2012; 2: 254\u2013265.","journal-title":"Quant Imaging Med Surg"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-019-04409-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.210484"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229127"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.12.014"},{"key":"e_1_3_3_13_2","article-title":"Low-frequency whole-body vibration can enhance cartilage degradation with slight changes in subchondral bone in mice with knee osteoarthritis and does not have any morphologic effect on normal joints","volume":"18","author":"Wang H","year":"2023","unstructured":"Wang H, et al. Low-frequency whole-body vibration can enhance cartilage degradation with slight changes in subchondral bone in mice with knee osteoarthritis and does not have any morphologic effect on normal joints. PLOS One 2023; 18: e0270074.","journal-title":"PLOS One"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022392"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/WOR-182699"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980115)17:1<101::AID-SIM727>3.0.CO;2-E"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017160681"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29432"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2021.101088"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.03.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120954"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-011-0259-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25554"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26771"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110759"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318242a4d3"},{"key":"e_1_3_3_28_2","first-page":"414","article-title":"Effects of whole body vibration on the neuromuscular amplitude of vastus lateralis muscle","volume":"16","author":"Borges DT","year":"2017","unstructured":"Borges DT, Macedo LB, Lins CAA, et al. Effects of whole body vibration on the neuromuscular amplitude of vastus lateralis muscle. J Sports Sci Med 2017; 16: 414\u2013420.","journal-title":"J Sports Sci Med"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.720905"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.5960\/dzsm.2018.357"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261476584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261476584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261476584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:17:32Z","timestamp":1787231852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261476584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/03000605261476584"],"URL":"https:\/\/doi.org\/10.1177\/03000605261476584","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"03000605261476584"}}