{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:22:27Z","timestamp":1788535347902,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The lactate-to-albumin ratio has been associated with adverse outcomes in various diseases. However, the impact of the lactate-to-albumin ratio on the prognosis of critically ill patients with chronic kidney disease remains unclear. Therefore, this study aimed to investigate the predictive ability of the lactate-to-albumin ratio for 28-day all-cause mortality in critically ill patients with chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 4271 critically ill patients with chronic kidney disease from the Medical Information Mart for Intensive Care IV database. The exposure factor was the lactate-to-albumin ratio, and the outcome was the 28-day mortality rate. Hazard ratios were computed along with their corresponding 95% confidence intervals using multivariate Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable Cox regression revealed that, compared with the Tertile 1 group, the hazard ratio for 28-day mortality was 1.55 (95% confidence interval: 1.26\u20131.92,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the Tertile 2 group and 1.91 (95% confidence interval: 1.54\u20132.36,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the Tertile 3 group. Kaplan\u2013Meier analysis demonstrated that the higher lactate-to-albumin ratio group had higher 28-day, 90-day, and 1-year mortality rates (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our study population, the lactate-to-albumin ratio was independently associated with 28-day all-cause mortality, and this ratio may provide incremental prognostic value when combined with established severity of illness scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261478720","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:39:26Z","timestamp":1788244766000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between lactate-to-albumin ratio and 28-day all-cause mortality in critically ill patients with chronic kidney disease: A retrospective cohort study from the Medical Information Mart for Intensive Care IV database"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1993-5224","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"first","affiliation":[{"name":"The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Lv","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine"},{"name":"Department of Intensive Care Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Ni","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine"},{"name":"Department of Intensive Care Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Hu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine"},{"name":"Department of Intensive Care Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, China"},{"name":"Department of Emergency, NanJing LiShui District Hospital of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Health Medicine, The Affiliated Jinling Hospital of Nanjing Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01568-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.12.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330673"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00250117"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.809292"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15260"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010307"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11472"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.1601"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0071"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4127-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.07.020"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-022-02763-x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-022-02902-4"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4519"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14764-z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1271391"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70114-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040297"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2027247"},{"key":"e_1_3_3_26_2","first-page":"513","article-title":"Comparison of four scoring systems for predicting ICU mortality in patients with sepsis","volume":"40","author":"Hu C","year":"2020","unstructured":"Hu C, Hu B, Li Z, et al. Comparison of four scoring systems for predicting ICU mortality in patients with sepsis. Nan Fang Yi Ke Da Xue Xue Bao 2020; 40: 513\u2013518.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2663-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01151-3"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/2150135120903977"},{"key":"e_1_3_3_30_2","first-page":"185","article-title":"The effect of acidosis on lactate removal by the perfused rat kidney","volume":"50","author":"Yudkin J","year":"1976","unstructured":"Yudkin J, Cohen RD. The effect of acidosis on lactate removal by the perfused rat kidney. Clin Sci Mol Med 1976; 50: 185\u2013194.","journal-title":"Clin Sci Mol Med"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.08.006"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05952-4"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1998.00438.x"},{"key":"e_1_3_3_34_2","article-title":"Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS","volume":"277","author":"Iglesias J","year":"1999","unstructured":"Iglesias J, Abernethy VE, Wang Z, et al. Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS. Am J Physiol 1999; 277: F711\u2013F722.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1071487"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-023-01697-7"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2022.100675"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.05.019"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255744"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1076121"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2021.1901306"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rce.2023.04.001"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.550182"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3681-2_2"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2015.05.003"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261478720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261478720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261478720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:50:39Z","timestamp":1788533439000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261478720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/03000605261478720"],"URL":"https:\/\/doi.org\/10.1177\/03000605261478720","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"article-number":"03000605261478720"}}