{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:07:47Z","timestamp":1789031267314,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nihon L'Or\u00e9al K.K."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A real-world observational study was conducted to evaluate the effectiveness, safety, and tolerability of an adjunctive dermocosmetic regimen in topical acne therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty Japanese patients who had been undergoing topical prescription treatment for &gt;4 weeks adjunctively used two dermocosmetic products, a facial cleanser and moisturizer cream for 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Global Evaluation Acne scale score, sebum production, skin findings, subjective symptoms, and patient quality of life were significantly improved after 3 months dermocosmetics of use. Tolerability for the dermocosmetics use was rated as \u201cwell-tolerated\u201d or \u201ctolerated\u201d by 75.5% of physicians and 73.5% of patients. Satisfaction with dermocosmetics use was high, with 87.5% of physicians and 92.0% of patients rating their satisfaction level as \u201cvery satisfied\u201d or \u201csatisfied.\u201d Most patients (86.0%) agreed or strongly agreed that they preferred using the study dermocosmetics over their previous cosmetics. Furthermore, 70.0% and 72.0% of the patients agreed that the dermocosmetic facial cleanser and moisturizing cream, respectively, improved the tolerability of their acne treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that the dermocosmetic regimen involving the use of a facial cleanser and moisturizing cream, when used in combination with topical prescription drugs is beneficial, well-tolerated, and acceptable among patients for the treatment of acne in real-world routine clinical practice in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261479490","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:52:38Z","timestamp":1788781958000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An adjunctive dermocosmetic regimen improves clinical outcomes and tolerability in Japanese patients on topical acne therapy: A real-world observational study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-5178","authenticated-orcid":false,"given":"Ichiro","family":"Kurokawa","sequence":"first","affiliation":[{"name":"Meiwa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Kobayashi Dermatology Clinic, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Nomura Dermatology Clinic, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Kojinkai Sapporo Skin Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Li","sequence":"additional","affiliation":[{"name":"Nihon L'Or\u00e9al K.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13548"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00594-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1599491"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04416.x"},{"key":"e_1_3_3_7_2","article-title":"Focus on cosmeceuticals: Definitions, regulations and a review of the market","volume":"3","author":"Varcin M","year":"2016","unstructured":"Varcin M, Knapen C. 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Medical Consultation & New Remedies 2024; 61: 349\u2013357. [in Japanese].","journal-title":"Medical Consultation & New Remedies"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.5603\/fd.97344"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2009.00504.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb02521.x"},{"key":"e_1_3_3_19_2","first-page":"407","article-title":"Japanese Dermatological association guidelines: guidelines for the treatment of acne vulgaris and rosacea 2023","volume":"133","author":"Yamasaki K","year":"2023","unstructured":"Yamasaki K, Akamatsu H, Omori R, et al. Japanese Dermatological association guidelines: guidelines for the treatment of acne vulgaris and rosacea 2023. 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