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Although global cellular proportions remained statistically stable across patient cohorts, disease progression was characterized by distinct cell-intrinsic transcriptomic shifts and subset-specific remodeling. This landscape was highlighted by the systematic peripheral depletion of homeostatic \u201cguardian\u201d monocytes, alongside functional disruptions in natural killer and B-cell states, and a severe-stage-specific accumulation of exhausted T cells. Consequently, circulating intercellular communication networks were broadly attenuated in infected groups, featuring diminished receptor\u2013ligand interactions between peripheral dendritic cells and na\u00efve CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, driven by cell-intrinsic transcriptional rewiring rather than shifts in underlying cell frequencies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tuberculosis progression involves profound peripheral immune remodeling marked by the systemic attrition of circulating homeostatic populations and altered blood interactome dynamics. This preliminary atlas provides an exploratory framework for potential therapeutic interventions in severe tuberculosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261480907","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:18:36Z","timestamp":1788146316000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A single-cell atlas of peripheral immunity suggests immune subset attrition during tuberculosis dissemination"],"prefix":"10.1177","volume":"54","author":[{"given":"Hairui","family":"Jiang","sequence":"first","affiliation":[{"name":"Bengbu Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Bengbu Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Bengbu Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-0105","authenticated-orcid":false,"given":"Dapeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Bengbu Medical University"},{"name":"Bengbu Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfcm.JFCM_106_18"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00763-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237574"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210915"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02839-22"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.871106"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03589-z"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00311"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102397"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540749"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.842858"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.635511"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02993"},{"key":"e_1_3_3_19_2","article-title":"Role of B cells in mycobacterium tuberculosis infection","volume":"11","author":"Stewart P","year":"2023","unstructured":"Stewart P, Patel S, Comer A, et al. 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