{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:02:36Z","timestamp":1789722156668,"version":"4.0.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Natural Science Foundation of Anhui Education Department","award":["2023AH053187, 2023AH040406 and 2025AHGXZK30093"],"award-info":[{"award-number":["2023AH053187, 2023AH040406 and 2025AHGXZK30093"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the current status, challenges, and development needs of the drug clinical trial industry in Anhui Province, central China, and to provide empirical evidence to support its high-quality development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study administered a questionnaire survey to 453 practitioners across multiple drug clinical trial institutions in Anhui Province (crude response rate, 63.9%; valid response rate, 62.9%). The survey collected data on demographic characteristics, work-related factors, perceived barriers and facilitators, and job satisfaction. Descriptive statistics, subgroup comparisons with Bonferroni correction, and ordinal logistic regression were used for data analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical research coordinators accounted for 32.01% of respondents, whereas biorepository managers accounted for only 0.44%. Respondents with a pharmacy background comprised 41.72%, whereas those with a clinical medicine background accounted for 30.46%. Only 54.30% of respondents reported proficiency in operating electronic data capture systems. The main reported challenges included difficulty recruiting trial participants (77.70%), low public awareness (68.21%), and insufficient self-reported digital literacy among practitioners (48.34%). A total of 90.29% of respondents supported the establishment of clinical trial\u2013related academic programs in higher medical education. Improving professional competency was identified as the most important measure (76.38%), followed by optimizing regulatory systems (12.80%). Overall, 69.09% of practitioners reported satisfaction with their career development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical trial practitioners in Anhui Province face prominent challenges, including difficulties in participant recruitment, an imbalanced workforce structure across job roles, insufficient digital literacy, and complex management processes. Based on these findings, several evidence-informed directions are proposed: strengthening public education, optimizing talent training, promoting digital infrastructure development, and enhancing regional coordination. These measures may facilitate the high-quality development of drug clinical trials in Anhui Province, central China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261485068","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:22:38Z","timestamp":1789543358000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Barriers and evidence-informed strategies for the high-quality development of drug clinical trials in Anhui Province, central China: A cross-sectional survey"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9235-3624","authenticated-orcid":false,"given":"Xiaobei","family":"Liu","sequence":"first","affiliation":[{"name":"Anqing Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Ren","sequence":"additional","affiliation":[{"name":"Anqing Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Deng","sequence":"additional","affiliation":[{"name":"Anqing Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Anqing Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Anqing Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Anqing Medical College"},{"name":"The First Affiliated Hospital of Bengbu Medical University"},{"name":"Key Laboratory of Pharmaceutical Research and Clinical Evaluation of Innovative Drugs, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Bengbu Medical University"},{"name":"Key Laboratory of Pharmaceutical Research and Clinical Evaluation of Innovative Drugs, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Shentu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Global Status Report on Clinical Research","author":"World Health Organization","year":"2021","unstructured":"World Health Organization. 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