{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:13Z","timestamp":1792787713009,"version":"4.5.0"},"reference-count":73,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nanjing Jinling Hospital Postdoctoral Research Foundation","award":["96015"],"award-info":[{"award-number":["96015"]}],"id":[{"id":"https:\/\/ror.org\/04kmpyd03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Jiangsu Funding Program for Excellent Postdoctoral Talent","award":["2024ZB573"],"award-info":[{"award-number":["2024ZB573"]}]},{"name":"Basic Research Program of Jiangsu","award":["BK20251678"],"award-info":[{"award-number":["BK20251678"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify metabolism-related genes associated with osteoporosis and evaluate their diagnostic potential through integrative transcriptomic analysis and clinical validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-cell RNA sequencing data from GSE169396 were analyzed using the Seurat package to investigate interactions between monocytes and other cell types. Metabolic pathway alterations in osteoporosis were evaluated using single-sample gene set enrichment analysis. Differentially expressed genes were intersected with metabolism-related genes to identify differentially expressed metabolism-related genes. Key metabolic genes were screened using the least absolute shrinkage and selection operator, support vector machine-recursive feature elimination, and Boruta algorithms, and a logistic regression model was established to assess their diagnostic value. External quantitative reverse transcription polymerase chain reaction validation was performed using peripheral blood mononuclear cells from patients with osteoporosis and healthy controls. Receiver operating characteristic curve analysis was used to evaluate the predictive performance of individual genes and the combined model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Single-cell interaction analysis revealed close communication between monocyte subsets and hematopoietic stem cells, endothelial cells, cDC2, cDC1, T cells, and plasmacytoid dendritic cells. Significant alterations were observed in valine, leucine, and isoleucine biosynthesis; purine metabolism; fatty acid biosynthesis and elongation; ascorbate and aldarate metabolism; and steroid biosynthesis. Intersection analysis identified 11 differentially expressed metabolism-related genes from 232 metabolism-related genes and 395 differentially expressed genes. Integrative machine learning identified seven key metabolic genes: ADSL, BCAT1, BCAT2, PDE8A, NPR2, SOAT2, and XDH. External validation confirmed significant differential expression of these genes between patients with osteoporosis and healthy controls. The logistic regression model showed excellent diagnostic performance, with an area under the curve of 0.935, whereas all individual genes achieved area under the curve values above 0.7. Gene set enrichment analysis indicated that these genes were enriched in pathways related to G protein\u2013coupled receptor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified seven key metabolic genes associated with osteoporosis, namely, ADSL, BCAT1, BCAT2, PDE8A, NPR2, SOAT2, and XDH, and demonstrated their promising diagnostic potential. These findings provide new insights into the metabolic mechanisms underlying osteoporosis and may support the development of future diagnostic biomarkers and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261491503","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:08:21Z","timestamp":1790647701000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0111-3029","authenticated-orcid":false,"given":"Yunfei","family":"He","sequence":"first","affiliation":[{"name":"Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Shi","sequence":"additional","affiliation":[{"name":"Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-1555","authenticated-orcid":false,"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13059-020-01997-2","article-title":"Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts","volume":"21","author":"Mullin BH","year":"2020","unstructured":"Mullin BH, Tickner J, Zhu K, et al. Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts. Genome Biol 2020; 21: 80.","journal-title":"Genome Biol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0140-6736(25)01385-6","article-title":"Osteoporosis","volume":"406","author":"Ye C","year":"2025","unstructured":"Ye C, Ebeling P, Kline G. Osteoporosis. Lancet 2025; 406: 2003\u20132016.","journal-title":"Lancet"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-025-07642-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziad006","article-title":"A protocol for the prospective study of urinary cadmium with risk of fracture, bone loss, and muscle loss","volume":"8","author":"de la Bastide C","year":"2024","unstructured":"de la Bastide C, Soares L, Lui LY, et al. A protocol for the prospective study of urinary cadmium with risk of fracture, bone loss, and muscle loss. JBMR Plus 2024; 8: ziad006.","journal-title":"JBMR Plus"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20190041"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02141-x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00757-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41413-024-00374-0","article-title":"Metabolic reprogramming in skeletal cell differentiation","volume":"12","author":"Bertels JC","year":"2024","unstructured":"Bertels JC, He G, Long F. Metabolic reprogramming in skeletal cell differentiation. Bone Res 2024; 12: 57.","journal-title":"Bone Res"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/s12964-025-02453-z","article-title":"The hidden driver of osteoporosis: mitochondria-dominated inflammation","volume":"23","author":"Yan B","year":"2025","unstructured":"Yan B, Ju W, Xue H, et al. The hidden driver of osteoporosis: mitochondria-dominated inflammation. Cell Commun Signal 2025; 23: 450.","journal-title":"Cell Commun Signal"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117541"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19196-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203124"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.7150\/ijbs.82177","article-title":"Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP\/TEAD4\/ACADL axis in hepatocellular carcinoma","volume":"19","author":"Cai J","year":"2023","unstructured":"Cai J, Chen T, Jiang Z, et al. Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP\/TEAD4\/ACADL axis in hepatocellular carcinoma. Int J Biol Sci 2023; 19: 2114\u20132131.","journal-title":"Int J Biol Sci"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08460"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/39.2.269"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3192"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4314"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-01045-4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012487302797"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i11"},{"key":"e_1_3_3_27_2","article-title":"Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease","volume":"11","author":"Zhang G","year":"2025","unstructured":"Zhang G, Luo H, Lu X, et al. Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease. Heliyon 2025; 11: e41872.","journal-title":"Heliyon"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01622200"},{"key":"e_1_3_3_31_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4049\/jimmunol.1501558","article-title":"The IL-12 response of primary human dendritic cells and monocytes to toxoplasma gondii is stimulated by phagocytosis of live parasites rather than host cell invasion","volume":"196","author":"Tosh KW","year":"2016","unstructured":"Tosh KW, Mittereder L, Bonne-Annee S, et al. The IL-12 response of primary human dendritic cells and monocytes to toxoplasma gondii is stimulated by phagocytosis of live parasites rather than host cell invasion. J Immunol 2016; 196: 345\u2013356.","journal-title":"J Immunol"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.vaccine.2012.05.035","article-title":"Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72\/AS01 as compared to the M72\/AS02 and Mtb72F\/AS02 tuberculosis candidate vaccine formulations: a randomized trial","volume":"31","author":"Leroux-Roels I","year":"2013","unstructured":"Leroux-Roels I, Forgus S, De Boever F, et al. Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72\/AS01 as compared to the M72\/AS02 and Mtb72F\/AS02 tuberculosis candidate vaccine formulations: a randomized trial. Vaccine 2013; 31: 2196\u20132206.","journal-title":"Vaccine"},{"key":"e_1_3_3_33_2","doi-asserted-by":"crossref","first-page":"107394","DOI":"10.1016\/j.jbc.2024.107394","article-title":"Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1alpha-XBP1\u2005s pathway","volume":"300","author":"Yu X","year":"2024","unstructured":"Yu X, Ren Z, Wang Y, et al. Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1alpha-XBP1\u2005s pathway. J Biol Chem 2024; 300: 107394.","journal-title":"J Biol Chem"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102529"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00223-015-9968-6","article-title":"Effect of vitamin B12 and folic acid supplementation on bone mineral density and quantitative ultrasound parameters in older people with an elevated plasma homocysteine level: b-PROOF, a randomized controlled trial","volume":"96","author":"Enneman AW","year":"2015","unstructured":"Enneman AW, Swart KM, van Wijngaarden JP, et al. Effect of vitamin B12 and folic acid supplementation on bone mineral density and quantitative ultrasound parameters in older people with an elevated plasma homocysteine level: b-PROOF, a randomized controlled trial. Calcif Tissue Int 2015; 96: 401\u2013409.","journal-title":"Calcif Tissue Int"},{"key":"e_1_3_3_36_2","article-title":"Monocytes and macrophages: origin, homing, differentiation, and functionality during inflammation","volume":"10","author":"Dash SP","year":"2024","unstructured":"Dash SP, Gupta S, Sarangi PP. Monocytes and macrophages: origin, homing, differentiation, and functionality during inflammation. Heliyon 2024; 10: e29686.","journal-title":"Heliyon"},{"key":"e_1_3_3_37_2","article-title":"Macrophage signaling pathways in health and disease: from bench to bedside applications","volume":"6","author":"Chi Y","year":"2025","unstructured":"Chi Y, Jiang H, Yin Y, et al. Macrophage signaling pathways in health and disease: from bench to bedside applications. MedComm (2020) 2025; 6: e70256.","journal-title":"MedComm (2020)"},{"key":"e_1_3_3_38_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.11005\/jbm.2023.30.2.127","article-title":"Origin of osteoclasts: osteoclast precursor cells","volume":"30","author":"Tsai J","year":"2023","unstructured":"Tsai J, Kaneko K, Suh AJ, et al. Origin of osteoclasts: osteoclast precursor cells. J Bone Metab 2023; 30: 127\u2013140.","journal-title":"J Bone Metab"},{"key":"e_1_3_3_39_2","doi-asserted-by":"crossref","first-page":"117019","DOI":"10.1016\/j.jep.2023.117019","article-title":"Kaempferol attenuates wear particle-induced inflammatory osteolysis via JNK and p38-MAPK signaling pathways","volume":"318","author":"Yu X","year":"2024","unstructured":"Yu X, Wu Q, Ren Z, et al. Kaempferol attenuates wear particle-induced inflammatory osteolysis via JNK and p38-MAPK signaling pathways. J Ethnopharmacol 2024; 318: 117019.","journal-title":"J Ethnopharmacol"},{"key":"e_1_3_3_40_2","doi-asserted-by":"crossref","first-page":"110651","DOI":"10.1016\/j.cellsig.2023.110651","article-title":"Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-\u03baB and MAPK signaling","volume":"106","author":"Yu X","year":"2023","unstructured":"Yu X, Yang B, Chen B, et al. Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-\u03baB and MAPK signaling. Cell Signal 2023; 106: 110651.","journal-title":"Cell Signal"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113784"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-016-0139-z"},{"key":"e_1_3_3_43_2","doi-asserted-by":"crossref","first-page":"0447","DOI":"10.34133\/research.0447","article-title":"Crosstalk between lipid metabolism and bone homeostasis: exploring intricate signaling relationships","volume":"7","author":"Xiao H","year":"2024","unstructured":"Xiao H, Li W, Qin Y, et al. Crosstalk between lipid metabolism and bone homeostasis: exploring intricate signaling relationships. Research 2024; 7: 0447.","journal-title":"Research"},{"key":"e_1_3_3_44_2","doi-asserted-by":"crossref","first-page":"17482","DOI":"10.3390\/ijms242417482","article-title":"Local effects of steroid hormones within the bone microenvironment","volume":"24","author":"Sandor LF","year":"2023","unstructured":"Sandor LF, Ragacs R, Gyori DS. Local effects of steroid hormones within the bone microenvironment. Int J Mol Sci 2023; 24: 17482.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_3_45_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13023-021-01731-6","article-title":"Clinical and molecular characterization of patients with adenylosuccinate lyase deficiency","volume":"16","author":"Mastrogiorgio G","year":"2021","unstructured":"Mastrogiorgio G, Macchiaiolo M, Buonuomo PS, et al. Clinical and molecular characterization of patients with adenylosuccinate lyase deficiency. Orphanet J Rare Dis 2021; 16: 112.","journal-title":"Orphanet J Rare Dis"},{"key":"e_1_3_3_46_2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1093\/hmg\/9.10.1501","article-title":"Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients","volume":"9","author":"Kmoch S","year":"2000","unstructured":"Kmoch S, Hartmannova H, Stiburkova B, et al. Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients. Hum Mol Genet 2000; 9: 1501\u20131513.","journal-title":"Hum Mol Genet"},{"key":"e_1_3_3_47_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hep.31685","article-title":"Targeting the de novo purine synthesis pathway through adenylosuccinate lyase depletion impairs liver cancer growth by perturbing mitochondrial function","volume":"74","author":"Jiang T","year":"2021","unstructured":"Jiang T, Sanchez-Rivera FJ, Soto-Feliciano YM, et al. Targeting the de novo purine synthesis pathway through adenylosuccinate lyase depletion impairs liver cancer growth by perturbing mitochondrial function. Hepatology 2021; 74: 233\u2013247.","journal-title":"Hepatology"},{"key":"e_1_3_3_48_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/21655979.2016.1206168","article-title":"Xanthine dehydrogenase: an old enzyme with new knowledge and prospects","volume":"7","author":"Wang CH","year":"2016","unstructured":"Wang CH, Zhang C, Xing XH. Xanthine dehydrogenase: an old enzyme with new knowledge and prospects. Bioengineered 2016; 7: 395\u2013405.","journal-title":"Bioengineered"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101882"},{"key":"e_1_3_3_50_2","first-page":"187","article-title":"Role of xanthine dehydrogenase and aging on the innate immune response of Drosophila","volume":"24","author":"Kim YS","year":"2001","unstructured":"Kim YS, Nam HJ, Chung HY, et al. Role of xanthine dehydrogenase and aging on the innate immune response of Drosophila. J Am Aging Assoc 2001; 24: 187\u2013193.","journal-title":"J Am Aging Assoc"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13060712"},{"key":"e_1_3_3_52_2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s43556-025-00349-5","article-title":"Osteoporosis: molecular pathogenesis and therapeutic interventions","volume":"6","author":"Zhang X","year":"2025","unstructured":"Zhang X, Liang Y, Zhang F, et al. Osteoporosis: molecular pathogenesis and therapeutic interventions. Mol Biomed 2025; 6: 98.","journal-title":"Mol Biomed"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.207S"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00775-3"},{"key":"e_1_3_3_55_2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55549","article-title":"A trans-eQTL network regulates osteoclast multinucleation and bone mass","volume":"9","author":"Pereira M","year":"2020","unstructured":"Pereira M, Ko JH, Logan J, et al. A trans-eQTL network regulates osteoclast multinucleation and bone mass. elife 2020; 9: e55549.","journal-title":"elife"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118645"},{"key":"e_1_3_3_57_2","doi-asserted-by":"crossref","DOI":"10.1111\/odi.12275","article-title":"Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets","volume":"21","author":"Ahmad F","year":"2015","unstructured":"Ahmad F, Murata T, Shimizu K, et al. Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets. Oral Dis 2015; 21: e25\u2013e50.","journal-title":"Oral Dis"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174015"},{"key":"e_1_3_3_59_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1124\/mol.111.076125","article-title":"Essential regulators of Leydig cell steroidogenesis","volume":"81","author":"Shimizu-Albergine M","year":"2012","unstructured":"Shimizu-Albergine M, Tsai LC, Patrucco E, et al. Essential regulators of Leydig cell steroidogenesis. Mol Pharmacol 2012; 81: 556\u2013566.","journal-title":"Mol Pharmacol"},{"key":"e_1_3_3_60_2","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.7150\/ijbs.113585","article-title":"The function of GPCRs in different bone cells","volume":"21","author":"Zhang Y","year":"2025","unstructured":"Zhang Y, Wang NN, Qiu ZH, et al. The function of GPCRs in different bone cells. Int J Biol Sci 2025; 21: 4736\u20134761.","journal-title":"Int J Biol Sci"},{"key":"e_1_3_3_61_2","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1523\/JNEUROSCI.0495-18.2018","article-title":"Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons","volume":"38","author":"Schmidt H","year":"2018","unstructured":"Schmidt H, Dickey DM, Dumoulin A, et al. Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons. J Neurosci 2018; 38: 9768\u20139780.","journal-title":"J Neurosci"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.02.002"},{"key":"e_1_3_3_63_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s13023-025-03936-5","article-title":"Identification of NPR2 gene mutations affecting chondrocyte differentiation in short stature through JAK2-STAT5","volume":"20","author":"Wei S","year":"2025","unstructured":"Wei S, He M, Zhang C, et al. Identification of NPR2 gene mutations affecting chondrocyte differentiation in short stature through JAK2-STAT5. Orphanet J Rare Dis 2025; 20: 392.","journal-title":"Orphanet J Rare Dis"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.07.018"},{"key":"e_1_3_3_65_2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/joim.13450","article-title":"Soat2 ties cholesterol metabolism to beta-oxidation and glucose tolerance in male mice","volume":"292","author":"Pramfalk C","year":"2022","unstructured":"Pramfalk C, Ahmed O, Pedrelli M, et al. Soat2 ties cholesterol metabolism to beta-oxidation and glucose tolerance in male mice. J Intern Med 2022; 292: 296\u2013307.","journal-title":"J Intern Med"},{"key":"e_1_3_3_66_2","doi-asserted-by":"crossref","first-page":"578194","DOI":"10.3389\/fendo.2020.578194","article-title":"Dual effects of lipid metabolism on osteoblast function","volume":"11","author":"Alekos NS","year":"2020","unstructured":"Alekos NS, Moorer MC, Riddle RC. Dual effects of lipid metabolism on osteoblast function. Front Endocrinol (Lausanne) 2020; 11: 578194.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101122"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13040578"},{"key":"e_1_3_3_69_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098953","article-title":"Acute sterol O-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion","volume":"9","author":"Marshall SM","year":"2014","unstructured":"Marshall SM, Gromovsky AD, Kelley KL, et al. Acute sterol O-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion. PLOS One 2014; 9: e98953.","journal-title":"PLOS One"},{"key":"e_1_3_3_70_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13105-017-0596-7","article-title":"Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption","volume":"74","author":"Eaton MS","year":"2018","unstructured":"Eaton MS, Weinstein N, Newby JB, et al. Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption. J Physiol Biochem 2018; 74: 3\u20138.","journal-title":"J Physiol Biochem"},{"key":"e_1_3_3_71_2","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1096\/fj.13-231233","article-title":"Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma","volume":"27","author":"He W","year":"2013","unstructured":"He W, Mazumder A, Wilder T, et al. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J 2013; 27: 3446\u20133454.","journal-title":"FASEB J"},{"key":"e_1_3_3_72_2","doi-asserted-by":"crossref","first-page":"116049","DOI":"10.1016\/j.isci.2026.116049","article-title":"Regulation of cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase and phosphodiesterase 8a","volume":"29","author":"Papaioannou G","year":"2026","unstructured":"Papaioannou G, Sato T, Houghton C, et al. Regulation of cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase and phosphodiesterase 8a. iScience 2026; 29: 116049.","journal-title":"iScience"},{"key":"e_1_3_3_73_2","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac005","article-title":"C-type natriuretic peptide-induced PKA activation promotes endochondral bone formation in hypertrophic chondrocytes","volume":"163","author":"Hirota K","year":"2022","unstructured":"Hirota K, Hirashima T, Horikawa K, et al. C-type natriuretic peptide-induced PKA activation promotes endochondral bone formation in hypertrophic chondrocytes. Endocrinology 2022; 163: bqac005.","journal-title":"Endocrinology"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.05.001"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261491503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261491503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261491503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:49:38Z","timestamp":1790941778000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261491503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/03000605261491503"],"URL":"https:\/\/doi.org\/10.1177\/03000605261491503","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"03000605261491503"}}