{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T08:46:57Z","timestamp":1791708417991,"version":"4.3.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Suzhou Gusu Health Talent Program","award":["GSWS2020059"],"award-info":[{"award-number":["GSWS2020059"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This pilot case\u2013control study aimed to preliminarily explore the potential association between urinary levels of zearalenone and the risk of Crohn's disease in a pediatric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot case\u2013control study was conducted in China. The participants included 32 pediatric patients with newly diagnosed or relapsed Crohn's disease (cases) and 30 healthy controls. Urinary concentrations of zearalenone were quantified using a validated high-performance liquid chromatography\u2013tandem mass spectrometry method. Data were analyzed using the Mann\u2013Whitney U test for group comparisons, and receiver operating characteristic analysis was performed to evaluate the preliminary discriminatory performance of zearalenone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Urinary zearalenone concentrations were significantly higher in children with Crohn's disease than in healthy controls (median 0.33 vs. 0.16 pg\/mL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Receiver operating characteristic analysis yielded an area under the curve of 0.92 (95% confidence interval: 0.85\u20131.00) for zearalenone, indicating good exploratory discriminatory ability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These exploratory findings suggest a preliminary link between elevated urinary zearalenone levels and pediatric Crohn's disease risk, potentially associated with its estrogenic properties. Given the pilot nature and limited sample size of this study, further large-scale longitudinal research is warranted to validate these observations and clarify the underlying biological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261492991","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:31:40Z","timestamp":1791430300000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary mycotoxin levels in children with Crohn's disease: A pilot case\u2013control study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7322-9556","authenticated-orcid":false,"given":"Kai","family":"Zheng","sequence":"first","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shen","sequence":"additional","affiliation":[{"name":"Kangda College of Nanjing Medical University Affiliated Nantong Mental Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqin","family":"Jin","sequence":"additional","affiliation":[{"name":"Children's Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Children's Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xue","sequence":"additional","affiliation":[{"name":"Children's Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2023.05.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1982"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000905"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.34"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.136"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.04.016"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12100619"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2197"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.07.030"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13040248"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13090593"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-030713-092431"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13050314"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2021.08.025"},{"key":"e_1_3_3_18_2","first-page":"796","article-title":"consensus on diagnosis and treatment of inflammatory bowel disease (2018, Beijing)","volume":"38","author":"Wu KC","year":"2018","unstructured":"Wu KC, Liang J, Ran ZH, et al. Chinese consensus on diagnosis and treatment of inflammatory bowel disease (2018, Beijing). Chin J Pract Intern Med 2018; 38: 796\u2013813.","journal-title":"Chin J Pract Intern Med"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9100330"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104689"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86788-w"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aap9415"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108856108"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127503"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111072"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21403"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11060333"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa065"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13010035"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12550-025-00612-2"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261492991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605261492991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605261492991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T08:22:06Z","timestamp":1791706926000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605261492991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/03000605261492991"],"URL":"https:\/\/doi.org\/10.1177\/03000605261492991","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"03000605261492991"}}