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Relevant quality of life studies are limited in socioeconomically and medically distinct regions of Western China. The present study aimed to address the regional gap and support targeted clinical public health strategies for long-term thyroid eye disease management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional survey was conducted among 306 patients with thyroid eye disease from 12 provinces, municipalities, and autonomous regions in Western China. Data were collected using a general demographic questionnaire, Graves\u2019 Ophthalmopathy Quality of Life (GO-QOL) questionnaire, Huaxi Emotional-Distress Index, and Athens Insomnia Scale. Multivariate linear regression was performed to identify independent factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean total GO-QOL score was 41.19\u2009\u00b1\u200919.38. Multivariate analysis revealed that GO-QOL of patients with diplopia, photophobia\/epiphora, restricted eye movement, and other ocular symptoms were lower by 9.024, 8.867, 9.416, and 4.159 points, respectively, than those of individuals without these symptoms (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001, except for \u201cother symptoms\u201d where\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006). For each 1-point increase in the Huaxi Emotional-Distress Index and Athens Insomnia Scale scores, the GO-QOL score decreased by 0.810 points (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 0.543 points (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007), respectively. Compared with patients with a Clinical Activity Score &lt;3, those with a Clinical Activity Score \u22653 had a mean GO-QOL score that was 5.626 points lower (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.041). The GO-QOL of patients with junior high school education was 5.434 points higher than that of those with a bachelor's degree or higher\n                      <jats:italic toggle=\"yes\">(p\u2009=\u2009<\/jats:italic>\n                      0.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The quality of life of patients with thyroid eye disease in Western China remains relatively low. Low educational level, ocular symptoms (diplopia, photophobia\/epiphora, and restricted motility), disease activity, emotional distress (anxiety\/depression), and sleep disorders are independent risk factors for poorer quality of life. These findings support a shift from single-modality ophthalmic care approach to a multidimensional, multidisciplinary strategy, integrating ocular symptom control, psychological support, and sleep improvement for long-term regional care of patients with thyroid eye disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261494375","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:30:15Z","timestamp":1791556215000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life and its modifying factors in patients with thyroid eye disease in Western China: A cross-sectional study"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2644-6228","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-juan","family":"Luo","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-hui","family":"Mei","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-su","family":"Yang","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-min","family":"He","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-xia","family":"Gao","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-4938","authenticated-orcid":false,"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2024.12.16"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.615993"},{"key":"e_1_3_3_4_2","first-page":"646","article-title":"Guidelines for the diagnosis and treatment of thyroid-associated ophthalmopathy in China (2022)","volume":"58","author":"The Ophthalmic Plastic and Orbital Disease Group of the Ophthalmology Branch of the Chinese Medical Association, and the Thyroid Branch of the Endocrinology Branch of the Chinese Medical Association","year":"2022","unstructured":"The Ophthalmic Plastic and Orbital Disease Group of the Ophthalmology Branch of the Chinese Medical Association, and the Thyroid Branch of the Endocrinology Branch of the Chinese Medical Association. 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