{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:48:33Z","timestamp":1791953313514,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare the recovery profiles after anesthesia with remimazolam reversed by flumazenil versus propofol among patients undergoing short-duration gynecological surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, single-blind, randomized trial, 86 patients were assigned to either the propofol group (n\u2009=\u200943, received propofol and remifentanil) or the remimazolam group (n\u2009=\u200943, received remimazolam and remifentanil). At the end of the surgery, patients in the propofol group received 2\u2005mg\/kg sugammadex, whereas those in the remimazolam group received 2\u2005mg\/kg sugammadex combined with 200\u2005\u03bcg flumazenil. Recovery was measured across immediate, intermediate, and long-term phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eye-opening and extubation times were significantly shorter in the remimazolam group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001). However, the the postanesthetic care unit stay times were significantly longer in this group due to institutional safety protocols (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001). No statistical differences were found in the Quality of Recovery-15\u2005K scores or other long-term recovery profiles at 4\u2005h or 1 day postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Remimazolam\u2013flumazenil significantly improved immediate recovery; however, its effects on the broader recovery trajectory were not significantly different from those of propofol, the most commonly used drug. Although Quality of Recovery-15\u2005K scores were numerically higher in the remimazolam group, the difference was not statistically significant.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial registration:<\/jats:bold>\n                      Clinical Research Information Service (CRIS), KCT0008314.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605261495755","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:17:43Z","timestamp":1791800263000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of recovery profiles after anesthesia with remimazolam and flumazenil versus propofol for short-duration gynecological surgery: A prospective, randomized, single-blind trial"],"prefix":"10.1177","volume":"54","author":[{"given":"Yoon Sook","family":"Lee","sequence":"first","affiliation":[{"name":"Korea University Ansan Hospital","place":["Republic of Korea"]},{"name":"Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Seongnam Citizens Medical Centre","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ha","family":"Park","sequence":"additional","affiliation":[{"name":"Korea University Ansan Hospital","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea University Ansan Hospital","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-8573","authenticated-orcid":false,"given":"Eunsu","family":"Choi","sequence":"additional","affiliation":[{"name":"Korea University Ansan Hospital","place":["Republic of Korea"]},{"name":"Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002103"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.0804"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.09.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000002069"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.165506"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2004.46.2.213"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000877"},{"key":"e_1_3_3_9_2","article-title":"CONSORT 2025 Statement: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell S","year":"2025","unstructured":"Hopewell S, Chan AW, Collins GS, et al. 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