{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:43:33Z","timestamp":1777725813230,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1973,1,1]],"date-time":"1973-01-01T00:00:00Z","timestamp":94694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1973,1]]},"abstract":"<jats:p>A randomized, comparative trial was carried out in 100 patients with trichomonal vaginitis to compare the efficacy and toleration of a single 2 g dose of tinidazole and metronidazole. Tinidazole produced parasitological cure in 94% of patients (47\/50) and a satisfactory clinical response in 96% of patients (48\/50); for metronidazole the figures were 64% (32\/50) and 72% (36\/50) respectively. Side-effects were reported by 52% of patients (26\/50) on tinidazole and 82% of patients (41\/50) on metronidazole. Severity of side-effects and their frequency per patient were significantly less (p&lt;0.05 to 0.01) with tinidazole than with metronidazole. Statistical evaluation of the results showed that tinidazole was significantly better than metronidazole with respect to parasitological cure (p&lt;0.01) and clinical improvement (p&lt;0.01) and also with regard to the incidence and intensity of side effects (p&lt;0.01).<\/jats:p>","DOI":"10.1177\/030006057300100210","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T19:26:59Z","timestamp":1484681219000},"page":"438-441","source":"Crossref","is-referenced-by-count":1,"title":["Single-Dose Treatment of Trichomonal Vaginitis: A Comparison of Tinidazole and Metronidazole"],"prefix":"10.1177","volume":"1","author":[{"given":"R","family":"Anjaneyulu","sequence":"first","affiliation":[{"name":"Professor and Head, Department of Obstetrics and Gynaecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Gupte","sequence":"additional","affiliation":[{"name":"Research Scholar, B. J. Medical College and Sassoon General Hospitals, Poona, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Desai","sequence":"additional","affiliation":[{"name":"Professor of Biochemistry, B. J. Medical College and Sassoon General Hospitals, Poona, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1973,1,1]]},"reference":[{"key":"bibr1-030006057300100210","first-page":"456","volume":"47","author":"Csonka G W","year":"1971","journal-title":"British Journal of Venereal Diseases"},{"key":"bibr2-030006057300100210","unstructured":"Faust E C, Russell P F (1964) Clinical Parasitology, 6th ed., p. 100, Lea & Febiger, Philadelphia."},{"key":"bibr3-030006057300100210","unstructured":"Garrod L P, Lambert H P, O'Grady F, Waterworth P M (1973) Antibiotic and Chemotherapy, 4th edn., p.50, Churchill Livingstone. Edinburgh and London."},{"key":"bibr4-030006057300100210","unstructured":"Howes H L, Lynch J E, Kivlin J L (1969) Tinidazole, a new antiprotozoal agent: effect on Trichomonas and other protozoa. Antimicrobial Agents and Chemotherapy p.261."},{"key":"bibr5-030006057300100210","doi-asserted-by":"publisher","DOI":"10.1185\/03007997409113627"},{"key":"bibr6-030006057300100210","doi-asserted-by":"publisher","DOI":"10.1185\/03007997409113636"},{"key":"bibr7-030006057300100210","first-page":"148","volume":"50","author":"Wallin J","year":"1974","journal-title":"British Journal of Venereal Diseases"},{"key":"bibr8-030006057300100210","first-page":"65","volume":"48","author":"Woodcock K R","year":"1972","journal-title":"British Journal of Venereal Diseases"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057300100210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057300100210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:36Z","timestamp":1777459416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057300100210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,1]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1973,1]]}},"alternative-id":["10.1177\/030006057300100210"],"URL":"https:\/\/doi.org\/10.1177\/030006057300100210","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,1]]}}}