{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:41:24Z","timestamp":1777725684936,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1975,5,1]],"date-time":"1975-05-01T00:00:00Z","timestamp":168134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1975,5]]},"abstract":"The drug combination including isoxsuprine 10 mg, acetaminophen 250 mg and caffeine 30 mg was administered to 80 patients divided into two groups, 40 with premenstrual tension and 40 with clinically diagnosed primary dysmenorrhoea.<\/jats:p>\n The study was carried out by the double-blind method and the patients were distributed at random. The results obtained show an excellent or very good response in 95% of cases of premenstrual tension and in 92\u00b75% of cases of dysmenorrhoea.<\/jats:p>\n When the overall effectiveness of the compound in both conditions is considered, we find it to be 93\u00b775%.<\/jats:p>\n A general discussion of the findings is presented in relation to age, civil status, time of appearance of dysmenorrhoea, nature of pain, accompanying symptoms, previous treatment, other non-drug therapies, results obtained, time within which symptoms were alleviated, total dose of the drug and side-effects.<\/jats:p>\n It is concluded that the orally-administered therapeutic combination is effective in both dysmenorrhoea and premenstrual tension.<\/jats:p>","DOI":"10.1177\/030006057500300309","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T16:02:20Z","timestamp":1484064140000},"page":"194-201","source":"Crossref","is-referenced-by-count":3,"title":["Isoxsuprine in Primary Dysmenorrhoea Its Effectiveness in Premenstrual Tension"],"prefix":"10.1177","volume":"3","author":[{"given":"Juan","family":"Gallegos-Torres","sequence":"first","affiliation":[{"name":"Gineco-Obstetra, Acreditalo por el Consejo Mexicano de Ginecologia y Obstetricia. Centro Gineco-Pediatrico Privado, Sinaloa 106 8\u00b0 Piso, Mexico 7, DF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Flores-Mercado","sequence":"additional","affiliation":[{"name":"Gineco-Obstetra, Acreditalo por el Consejo Mexicano de Ginecologia y Obstetricia. Centro Gineco-Pediatrico Privado, Sinaloa 106 8\u00b0 Piso, Mexico 7, DF"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1975,5,1]]},"reference":[{"key":"bibr1-030006057500300309","first-page":"111","volume":"20","author":"Alvarez-Bravo A","year":"1962","journal-title":"Obstetrics and Gynaecology Latin America"},{"key":"bibr2-030006057500300309","first-page":"442","volume":"17","author":"Bishop E H","year":"1961","journal-title":"Obstetrics & Gynaecology"},{"key":"bibr3-030006057500300309","unstructured":"Medical Information Department Bristol Myers Company International Division (Nov 1st, 1971) New York Medical Department. pp 9\u201310. (Information available from Bristol Laboratories)"},{"key":"bibr4-030006057500300309","first-page":"497","volume":"32","author":"Flores-Mercado F","year":"1972","journal-title":"Ginecologia y obstetricia de M\u00e9xico"},{"key":"bibr5-030006057500300309","unstructured":"Fluhmann F (1958) Tratamiento de los Trastornos Menstruales. (Treatment of menstrual disorders), 1st edition, p 285. Edit Interamericana. M\u00e9xico, D F"},{"key":"bibr6-030006057500300309","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)36199-3"},{"key":"bibr7-030006057500300309","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1970.tb00027.x"},{"key":"bibr8-030006057500300309","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1970.tb00035.x"},{"key":"bibr9-030006057500300309","unstructured":"Israel L S, Mazer C (1961) Premenstrual Tension as an Abnormal Manifestation of the Menstrual Cycle. Menstrual Disorder and Sterility. 4th edition, p 175. Paul B Hoeber, Inc New York"},{"key":"bibr10-030006057500300309","unstructured":"Clinical Reports, Mead Johnson Company Research Files (October 1970) p 15. (Information available from Mead Johnson Laboratories)"},{"key":"bibr11-030006057500300309","unstructured":"Novack R E, Jones S G, Jones W H (1966) Problemas Diversos en Ginecologia. Tratado de Ginecologia. (Miscellaneous problems in gynaecology. Treatise on gynaecology), 6th edition, p 83. Edit Interamericana. M\u00e9xico, D F"},{"key":"bibr12-030006057500300309","first-page":"512","volume":"8","author":"Ratowsky A","year":"1961","journal-title":"Clinical Medicine"},{"key":"bibr13-030006057500300309","first-page":"3","volume":"13","author":"Urrutia R M","year":"1958","journal-title":"Ginecologia y obstetricia de Mexico"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057500300309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057500300309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:04Z","timestamp":1777459384000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057500300309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,5]]}},"alternative-id":["10.1177\/030006057500300309"],"URL":"https:\/\/doi.org\/10.1177\/030006057500300309","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,5]]}}}