{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:47:34Z","timestamp":1777726054110,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1976,1,1]],"date-time":"1976-01-01T00:00:00Z","timestamp":189302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:p>Thirty children over the age of one month were treated with amikacin ( BBK8), a new aminoglycoside derived from kanamycin A, with three intramuscular dosage schedules. Each group consisted of ten patients. The first received 7.5 mg\/kg\/12 hours, the second 7.5 mg\/kg\/24 hours and the third, 3.75 mg\/kg\/12 hours. The infections and the bacteria were similar in all three groups: pyelonephritis, abscesses of soft tissues, infected wounds, septicaemia, superinfected empyema, gastro-enteritis, chronic otitis media; the bacteria were E. coli, Klebsiella, Pseudomonas and Salmonella. A were sensitive by the Kirby-Bauer method, although two were resistant by dilution in Petri dish. Of the thirty patients, twenty four (80%) were cured. The schedule of 3.75 mg\/kg\/12 hours was as effective as the schedule of7.5 mg\/kg\/12 hours for infections such as pyelonephritis, superficial abcesses, contaminated wounds, gastro-enteritis and sepsis. The cases with infections localized in rather unaccessible sites required double the dose and strict drainage and cleanliness. Plasma levels with the administration of 3.75 mg\/kg fluctuated between 8.3 and 12.6 mcg\/ml; with 7.5 mg\/kg they fluctuated between 8.6 and 13.1. The minimum inhibitory level ( MIL) for the majority of the bacteria was 1.25 mcg\/ml. No toxic reactions were observed.<\/jats:p>","DOI":"10.1177\/030006057600400101","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T23:53:41Z","timestamp":1484524421000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["Amikacin (BBK8) in Infections Due to Gram-Negative Organisms in Children over the Age of One Month"],"prefix":"10.1177","volume":"4","author":[{"given":"J I","family":"Ramirez","sequence":"first","affiliation":[{"name":"Paediatric Resident, School of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Trujillo","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Antioquia, Colombia; Chief of the Infectious Diseases Service, Children's Hospital, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Uribe","sequence":"additional","affiliation":[{"name":"Chief, Bacteriology Section, San Vicente de Paul Hospital, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy H","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Technician, Infectious Diseases Laboratory, Children's Hospital, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Luisa","family":"de Vidal","sequence":"additional","affiliation":[{"name":"Technician, Infectious Diseases Laboratory, Children's Hospital Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1976,1,1]]},"reference":[{"key":"bibr1-030006057600400101","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4_ts.493"},{"key":"bibr2-030006057600400101","unstructured":"Laboratories Bristol (1974) BB-K8 Clinical Summary, Nov 21, 1974"},{"key":"bibr3-030006057600400101","unstructured":"Calder\u00f3n G R, Duque G C, Morales R C, Montoya M S, Zuluaga P L, Gonzalez G, Trujillo S H, Uribe P A (1976) \u2018Incidencia y causas de flebitis por venoclisis en pacientes pedi\u00e1tricos en el Hospital Universitario San Vicente de Pa\u00fal, 1973\u2019. (Incidence and causes of phlebitis caused by venoclysis in pediatric patients at San Vicente de Pa\u00fal University Hospital, 1973). In press"},{"key":"bibr4-030006057600400101","unstructured":"King W, Cox C (1973) BB-K8, therapy of urinary tract infections: clinical and pharmacologic studies. 13th Interscience Conference on Antimicrobial Agents and Chemotherapy, September 19-21, 1973, 126"},{"key":"bibr5-030006057600400101","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300401"},{"key":"bibr6-030006057600400101","unstructured":"Mathias R,  (1974) A clinical and laboratory evaluation of Amikacin,\n                      Program and Abstracts.\n                      14\n                      th Interscience Conference on Antimicrobial Agents and Chemotherapy, September\n                      11-13, San Francisco, No. 329"},{"key":"bibr7-030006057600400101","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)32148-4"},{"key":"bibr8-030006057600400101","unstructured":"Periodic reports on\n                      in vitro\n                      sensitivity of bacteria isolated at San Vicente de Paul Hospital, Medellin, Colombia"},{"key":"bibr9-030006057600400101","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.5.2.143"},{"key":"bibr10-030006057600400101","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.19.4.573-579.1970"},{"key":"bibr11-030006057600400101","first-page":"307","volume":"9","author":"Steers E","year":"1959","journal-title":"Antibiotics and Chemotherapy"},{"key":"bibr12-030006057600400101","unstructured":"Tally F P,  (1974) The treatment of serious infections with amikacin (BB-K8). Program and Abstracts. 14\n                      th Interscience Conference on Antimicrobial Agents and Chemotherapy, September\n                      11-13, No. 331"},{"key":"bibr13-030006057600400101","unstructured":"Tayllor W A, Peters M B (1974) Therapeutic effectiveness of BB-K8 in Gramnegative bacterial infections. Program and Abstracts. 14\n                      th Interscience Conference on Antimicrobial Agents and Chemotherapy, September\n                      11-13, No. 330"},{"key":"bibr14-030006057600400101","first-page":"339","volume":"69","author":"Uribe P A","year":"1974","journal-title":"A Folha M\u00e9dica"},{"key":"bibr15-030006057600400101","unstructured":"Valdivieso M,  (1974) Amikacin therapy of infections in neutropenic patients. Program and Abstracts. 14\n                      th Interscience Conference on Antimicrobial Agents and Chemotherapy September\n                      11-13, 1974, No. 337"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057600400101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057600400101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:45Z","timestamp":1777459485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057600400101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,1]]}},"alternative-id":["10.1177\/030006057600400101"],"URL":"https:\/\/doi.org\/10.1177\/030006057600400101","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,1]]}}}