{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:47:52Z","timestamp":1777726072520,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1976,5,1]],"date-time":"1976-05-01T00:00:00Z","timestamp":199756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:p>Flurbiprofen and ibuprofen, two propionic acid derivatives with anti-inflammatory and analgesic activity, were compared in a double-blind multiclinic study in 195 patients with osteoarthritis of the peripheral joints. The patients were given 80 mg\/day flurbiprofen or 1600 mg\/day ibuprofen for six weeks. Pain, subjective evaluation and functional tests improved significantly in both groups. There were no statistically significant differences between the two treatments in any of the responses.<\/jats:p>\n                  <jats:p>Gastro-intestinal side-effects, generally mild, developed in 5-6% of the patients.<\/jats:p>","DOI":"10.1177\/030006057600400302","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T18:23:32Z","timestamp":1409855012000},"page":"152-157","source":"Crossref","is-referenced-by-count":14,"title":["Response of Osteoarthritis to Ibuprofen or Flurbiprofen"],"prefix":"10.1177","volume":"4","author":[{"given":"H R","family":"Mena","sequence":"first","affiliation":[{"name":"Assistant Clinical Professor of Medicine, Michigan State University and Research Associate, The Upjohn Company, Kalamazoo, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G E","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Professor of Medicine, Temple University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Giansiracusa","sequence":"additional","affiliation":[{"name":"Associate Clinical Professor of Medicine, University of California, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Ward","sequence":"additional","affiliation":[{"name":"Professor of Medicine, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gray","sequence":"additional","affiliation":[{"name":"Assistant Clinical Professor of Medicine, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1976,5,1]]},"reference":[{"key":"bibr1-030006057600400302","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1974.tb93775.x"},{"key":"bibr2-030006057600400302","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260040030018"},{"key":"bibr3-030006057600400302","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5943.496"},{"key":"bibr4-030006057600400302","doi-asserted-by":"crossref","unstructured":"Giansiracusa JE, Donaldson M S, Koonce ML, Lefton TE, Ruoff GE, Brooks CD (1975) Ibuprofen in osteoarthritis. 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