{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:05:58Z","timestamp":1777727158911,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:p>In a three-week study of 10,000 general practice patients with depressive illness, a single dose of maprotiline 75 mg at night was effective therapy in three-quarters of the patients who completed the study.<\/jats:p>\n                  <jats:p>At this dose the drug was well tolerated, and troublesome side-effects presented in only a small percentage of patients. Drowsiness was the most commonly reported side-effect, and the main reason for withdrawal of treatment.<\/jats:p>\n                  <jats:p>The drug was acceptable to most physicians, and in this study was used in a wide range of patients and over a broad spectrum of depressive illness.<\/jats:p>","DOI":"10.1177\/030006057700500107","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T19:37:08Z","timestamp":1409859428000},"page":"42-47","source":"Crossref","is-referenced-by-count":16,"title":["Maprotiline (Ludiomil\n                    <sup>\u00ae<\/sup>\n                    ) in Depression: A Report of a Monitored Release Study of 10,000 Patients in General Practice"],"prefix":"10.1177","volume":"5","author":[{"given":"W A","family":"Forrest","sequence":"first","affiliation":[{"name":"Senior Medical Adviser, CIBA Laboratories, Horsham, West Sussex, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1977,1,1]]},"reference":[{"key":"bibr1-030006057700500107","first-page":"475","volume":"35","author":"Ayd FJ","year":"1974","journal-title":"Diseases of the Nervous System"},{"key":"bibr2-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03240020053025"},{"key":"bibr3-030006057700500107","unstructured":"Ban T (1970) Tricyclic antidepressants; adverse reactions and their treatment. Psychopharmacology p, 283 (William and Wilkins, Baltimore 1969)"},{"key":"bibr4-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5844.7"},{"key":"bibr5-030006057700500107","doi-asserted-by":"crossref","DOI":"10.1177\/030006057500300607","volume":"3","author":"Forrest WA","year":"1975","journal-title":"Journal of International Medical Research"},{"key":"bibr6-030006057700500107","first-page":"39","volume":"16","author":"Gatley M S","year":"1968","journal-title":"Journal of the Royal College of General Practitioners"},{"key":"bibr7-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5857.18"},{"key":"bibr8-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197402282900905"},{"key":"bibr9-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1097\/00012995-197608000-00001"},{"key":"bibr10-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300209"},{"key":"bibr11-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300610"},{"key":"bibr12-030006057700500107","unstructured":"Riess W, Rajagopalan W, Keberle H (1972) The metabolism and pharmacokinetics of maprotiline. \u2018Depressive illness; diagnosis, assessment\u2019 treatment\u2018. Kielholz P (Ed). An international symposium p 140"},{"key":"bibr13-030006057700500107","unstructured":"Silverstone T, Forrest WA (1976) A comparison of maprotiline (Ludiomil\n                      \u00ae\n                      ) and amitriptyline in the treatment of depression in general practice. (In: Research and Clinical Investigation in Depression p 114. Ed Murphy J Eric, Cambridge Medical Publications Ltd, Northampton, England"},{"key":"bibr14-030006057700500107","volume":"3","author":"Trick KLK","year":"1975","journal-title":"Journal of International Medical Research"},{"key":"bibr15-030006057700500107","unstructured":"Vere DW (1970) Controlled trials to detect efficacy and toxicity. Training to meet tomorrow's needs. In: The principles and practice of clinical trials p 242 (Livingstone)"},{"key":"bibr16-030006057700500107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5465.790"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057700500107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057700500107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:45Z","timestamp":1777459725000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057700500107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1177\/030006057700500107"],"URL":"https:\/\/doi.org\/10.1177\/030006057700500107","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}